1-A-F-17. Similarity of neuromagnetic oscillatory changes during observation of actions in monozygotic twins
Mai OnishiToshihiko ArakiMasayuki HirataTakufumi YanagisawaAyumi TaniyamaK OmuraChika HondaKazuo HayakawaShiro Yorifuji
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Keywords:
Mirror neuron
Magnetoencephalography
Inferior parietal lobule
Inferior frontal gyrus
Trait
The aim of this study is to analyze the brain activity patterns during the observation of painful expressions and to establish the relationship between this activity and the scores obtained on the Interpersonal Reactivity Index (IRI).The study included twenty healthy, right-handed subjects (10 women). We conducted a task-based and resting-state functional magnetic resonance imaging (fMRI) study. The task involved observing pictures displaying painful expressions. We performed a region of interest (ROI) analysis focusing on the core regions of the sensorimotor mirror neuron system (MNS). Resting-state fMRI was utilized to assess the functional connectivity of the sensorimotor MNS regions with the rest of the cortex using a seed-to-voxel approach. Additionally, we conducted a regression analysis to examine the relationship between brain activity and scores from the IRI subtests.Observing painful expressions led to increased activity in specific regions of the frontal, temporal, and parietal lobes. The largest cluster of activation was observed in the left inferior parietal lobule (IPL). However, the ROI analysis did not reveal any significant activity in the remaining core regions of the sensorimotor MNS. The regression analysis demonstrated a positive correlation between brain activity during the observation of pain and the "empathic concern" subtest scores of the IRI in both the cingulate gyri and bilateral IPL. Finally, we identified a positive relationship between the "empathic concern" subtest of the IRI and the functional connectivity (FC) of bilateral IPLs with the bilateral prefrontal cortex and the right IFG.Observing expressions of pain triggers activation in the sensorimotor MNS, and this activation is influenced by the individual's level of empathy.
Mirror neuron
Inferior parietal lobule
Interpersonal Reactivity Index
Brain mapping
Supplementary motor area
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Mirror neurons have been proposed to underlie humans' ability to understand others' actions and intentions. Despite 2 decades of research, however, the exact computational and neuronal mechanisms implied in this ability remain unclear. In the current study, we investigated whether, in the absence of contextual cues, regions considered to be part of the human mirror neuron system represent intention from movement kinematics. A total of 21 participants observed reach-to-grasp movements, performed with either the intention to drink or to pour while undergoing functional magnetic resonance imaging. Multivoxel pattern analysis revealed successful decoding of intentions from distributed patterns of activity in a network of structures comprising the inferior parietal lobule, the superior parietal lobule, the inferior frontal gyrus, and the middle frontal gyrus. Consistent with the proposal that parietal regions play a key role in intention understanding, classifier weights were higher in the inferior parietal region. These results provide the first demonstration that putative mirror neuron regions represent subtle differences in movement kinematics to read the intention of an observed motor act.
Mirror neuron
Inferior parietal lobule
Superior parietal lobule
Middle frontal gyrus
Inferior frontal gyrus
Parietal lobe
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Mirror neurons got a great deal of attention from connoisseurs and in scientific reports. Mirror neurons have the capability of observation and execution of action to code both “my action and your action”. Firstly they were found in an area of f5 region of ventral premotor cortex and inferior parietal lobule of monkey brain. Mirror neuron system (MNS) is the driving force behind the great leap forward in human evolution. Both monkeys and human are born with MNS. Sensory or motor experience may trigger the development of mirror neurons. Adult group show an intrinsic difference between goal directed and non –goal directed action observation condition. Recently neurons with mirror characteristics have been found outside the rostral part of inferior parietal lobule and inferior frontal gyrus. Human neuroimaging experiments confirm a wide overlap between cortical areas in human and areas where mirror neurons have been reported in macaque monkey. Still there is a lack of studies about MNS in neurosurgical patients so the goal is to describe the application of an fMRI protocol to identify the MNS in patient with mass lesion in premotor area. The goal of this review was to give a brief explanation of MNS covering their origin, observation, execution, innateness, evolution, development, empathy and recent developments like fMRI, neuroimaging and mapping.
Mirror neuron
Inferior parietal lobule
Premotor cortex
Broca's area
Superior parietal lobule
Human brain
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Inferior parietal lobule
Mirror neuron
Superior parietal lobule
Premotor cortex
Inferior frontal gyrus
Parietal lobe
Frontal lobe
Angular gyrus
Superior frontal gyrus
Neural substrate
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Inferior parietal lobule
Frontal lobe
Parietal lobe
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This study examines the association between action and perception in the development of the human mirror system (HMS) in children from 4-7 years of age. Imitation is one mechanism that may promote associations between action and perception in the developing brain. Neuroimaging studies on adults have found activation of the same 3 areas in the brain, termed the Human Mirror System, both when participants imitate an action and when they are imitated. Using fMRI, we compared neural activation patterns in children during action production and observation both in isolation and in the context of imitation. We hypothesized that because both perception and action are required for imitation, the HMS will not be recruited during action or perception alone. Results revealed no overlapping activation in the 3 core areas of the HMS during observations and production of the same actions in isolation. In addition, the children's response pattern during imitation was somewhat different than the pattern previously shown in adults. Unlike adults, children showed no activation in the inferior parietal lobule during imitation tasks, but similar to adults, did recruit the inferior frontal gyrus and the superior temporal sulcus. These results demonstrate that imitation recruits different brain systems in the adult than in the child. We speculate that imitation recruits a temporal-parietal-frontal pathway in adults and a more direct temporal-frontal pathway in the child.
Mirror neuron
Superior temporal sulcus
Inferior frontal gyrus
Inferior parietal lobule
Superior parietal lobule
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The analysis of scale-free (i.e., 1/f power spectrum) brain activity has emerged in the last decade since it has been shown that low frequency fluctuations interact with oscillatory activity in electrophysiology, noticeably when exogenous factors (stimuli, task) are delivered to the human brain. However, there are some major difficulties in measuring scale-free activity in neuroimaging data: they are noisy, possibly nonstationary ... Here, we make use of multifractal analysis to better understand the biological meaning of scale-free activity recorded with Magnetoencephalography (MEG) data. On a cohort of 20 subjects, we demonstrate the presence of self-similarity on all sensors during rest and visually evoked activity. Also, we report significant multifractality on the norm of gradiometers. Finally, on the latter signals we show how self-similarity and multifractality are modulated between ongoing and evoked activity.
Magnetoencephalography
Multifractal system
Evoked activity
Premovement neuronal activity
Similarity (geometry)
Neurophysiology
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Parietofrontal pathways play an important role in visually guided motor control. In this pathway, hand manipulation-related neurons in the inferior parietal lobule represent 3-D properties of an object and motor patterns to grasp it. Furthermore, mirror neurons show visual responses that are concerned with the actions of others and motor-related activity during execution of the same grasping action. Because both of these categories of neurons integrate visual and motor signals, these neurons may play a role in motor control based on visual feedback signals. The aim of this study was to investigate whether these neurons in inferior parietal lobule including the anterior intraparietal area and PFG of macaques represent visual images of the monkey's own hand during a self-generated grasping action. We recorded 235 neurons related to hand manipulation tasks. Of these, 54 responded to video clips of the monkey's own hand action, the same as visual feedback during that action or clips of the experimenter's hand action in a lateral view. Of these 54 neurons, 25 responded to video clips of the monkey's own hand, even without an image of the target object. We designated these 25 neurons as "hand-type." Thirty-three of 54 neurons that were defined as mirror neurons showed visual responses to the experimenter's action and motor responses. Thirteen of these mirror neurons were classified as hand-type. These results suggest that activity of hand manipulation-related and mirror neurons in anterior intraparietal/PFG plays a fundamental role in monitoring one's own body state based on visual feedback.
Mirror neuron
Inferior parietal lobule
CLIPS
Eye–hand coordination
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There is much current debate about the existence of mirror neurons in humans. To identify mirror neurons in the inferior frontal gyrus (IFG) of humans, we used a repetition suppression paradigm while measuring neural activity with functional magnetic resonance imaging. Subjects either executed or observed a series of actions. Here we show that in the IFG, responses were suppressed both when an executed action was followed by the same rather than a different observed action and when an observed action was followed by the same rather than a different executed action. This pattern of responses is consistent with that predicted by mirror neurons and is evidence of mirror neurons in the human IFG.
Mirror neuron
Inferior frontal gyrus
Repetition (rhetorical device)
Broca's area
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Citations (504)
Mirror neurons got a great deal of attention from connoisseurs and in scientific reports. Mirror neurons have the capability of observation and execution of action to code both my action and your action. Firstly they were found in an area of f5 region of ventral premotor cortex and inferior parietal lobule of monkey brain. Mirror neuron system (MNS) is the driving force behind the great leap forward in human evolution. Both monkeys and human are born with MNS. Sensory or motor experience may trigger the development of mirror neurons. Adult group show an intrinsic difference between goal directed and non -goal directed action observation condition. Recently neurons with mirror characteristics have been found outside the rostral part of inferior parietal lobule and inferior frontal gyrus. Human neuroimaging experiments confirm a wide overlap between cortical areas in human and areas where mirror neurons have been reported in macaque monkey. Still there is a lack of studies about MNS in neurosurgical patients so the goal is to describe the application of an fMRI protocol to identify the MNS in patient with mass lesion in premotor area. The goal of this review was to give a brief explanation of MNS covering their origin, observation, execution, innateness, evolution, development, empathy and recent developments like fMRI, neuroimaging and mapping.
Mirror neuron
Inferior parietal lobule
Premotor cortex
Broca's area
Cite
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