Adolescence Mycosis Fungoides: An Unusual Presentation with Hypopigmentation
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Abstract:
Abstract Mycosis fungoides (M.F.) is a rare cutaneous malignancy of childhood and adolescence. The disease commonly presents with the classic sequence of erythematous patches and plaques. Hypopigmentation as the presenting symptom is distinctly rare. This is the 9th case report of M.F. presenting with hypopigmentation in a patient under 20 years of age. The disease was only partially controlled with PUVA therapy, necessitating nitrogen mustard treatment.Keywords:
Hypopigmentation
Presentation (obstetrics)
Hypopigmentation
Vitiligo
PUVA therapy
Ultraviolet a
Pigmentation disorder
Methoxsalen
Ultraviolet light
Ultraviolet therapy
Ultraviolet b
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An 89-year old patient had mycosis fungoides with extensive skin involvement and palpable but pathologically uninvolved lymph nodes. He was successfully treated with PUVA combined with topical 0.1% fluocinolone acetonide ointment. PUVA therapy is highly effective in the treatment of mycosis fungoides confined to the skin, especially in the elderly where more aggressive therapy may not be tolerated.
PUVA therapy
Fluocinolone acetonide
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Hypopigmentation
Vitiligo
Buttocks
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Hypopigmentation
Vitiligo
Melasma
Erythema
Pigmentation disorder
Milia
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Hypopigmentation
Vitiligo
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Skin pigmentation disorder is one of the common skin diseases. In general, skin gets its color from melanin pigment, which is produced by melanocytes in the skin. When these cells are damaged, they can negatively affect melanin production. Pigmentation disorders in the skin are classified as hyperpigmentation and hypopigmentation. Hyperpigmentation appears due to increased melanin in the skin. Typical hyperpigmentation disorders include post-inflammatory hyperpigmentation, melasma, solar lentigines, freckles, and café au lait macules. These conditions are generally benign but can be distressing to patients. Addison's disease and some other endocrine disorders may cause diffuse hyperpigmentation. Hypopigmentation is caused by a decrease in melanin production in the skin. Examples of hypopigmentation include vitiligo, albinism, fungal infections, and post-inflammatory hypopigmentation, for example after burns or psoriasis. The nine chapters in this book discuss the latest clinical and therapeutic findings on the most common skin pigmentation disorders and their effect on patients' quality of life.
Hypopigmentation
Vitiligo
Melasma
Pigmentation disorder
Melanosis
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Cutaneous T-cell lymphoma (CTCL) presenting with hypopigmented lesions is an uncommon clinical variant of the disease, usually described in dark-skinned patients. We report a case of hypopigmented CTCL in a 10-year-old boy. The disease has responded favorably to narrowband UVB therapy. This case illustrates the importance of clinical suspicion for mycosis fungoides in patients with widespread hypopigmentation.
Hypopigmentation
Cutaneous T-cell lymphoma
Vitiligo
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Citations (4)
Hypopigmentation
Poikiloderma
Peripheral T-cell lymphoma
Presentation (obstetrics)
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Hypopigmented, nonatrophic macules are an unusual manifestation of lesions of early mycosis fungoides. Presented herein is a patient with such lesions and an unusual mask-like hypopigmentation of the face. We review both the clinical and microscopic findings in this patient and in previously reported patients with hypopigmented lesions of mycosis fungoides. Finally, speculation is made as to the mechanisms of the hypopigmentation.
Hypopigmentation
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