Long-term Physical Activity and Inflammatory Biomarkers In Older Adults
Kristen M. BeaversFang‐Chi HsuScott IsomStephen B. KritchevskyTimothy R. ChurchBret H. GoodpasterMarco PahorBarbara J. Nicklas
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PURPOSE: To determine the effects of a 12-month physical activity intervention on inflammatory biomarkers in elderly men and women. METHODS: 424 elderly (aged 70-89 years), nondisabled, community-dwelling men and women at risk for physical disability were enrolled in a multicenter, single-blind, randomized controlled-trial. Participants were randomized to participate in either a 12-month moderate-intensity physical activity (PA) intervention or a successful aging (SA) health education intervention. Biomarkers of inflammation (IL-6sR, IL-1sRII, sTNFRI, sTNFRII, IL-8, IL-15, adiponectin, IL-1ra, IL-2sRa, and TNF-a) were measured at baseline, 6 and 12 months. RESULTS: After adjustment for gender, clinic site, diabetes status, and baseline outcome measure, IL-8 was the only inflammatory biomarker affected by the PA intervention (p=0.03). The adjusted mean IL-8 at month 12 was 9.9% (0.87 pg/mL) lower in the PA compared to the SA group. Secondary interaction analyses between baseline biomarker status and treatment showed one significant interaction (p=0.02) such that the PA intervention reduced IL-15 concentrations in participants with a baseline IL-15 above the median value of 1.67 g/mL. However, these associations were no longer significant after consideration for multiple comparisons. CONCLUSIONS: Overall, this study does not provide definitive evidence for an effect of regular exercise for altering systemic concentrations of the measured inflammatory biomarkers in older adults.This chapter contains sections titled: Introduction Adiponectin Structure and Post-Translational Modifications Significance and Bioactivity of Adiponectin Multimers Adiponectin and Liver Adiponectin and Skeletal Muscle Adiponectin and the Vasculature Adiponectin and the Brain Adiponectin Expression and Secretion Adiponectin Secretion Ectopic Adiponectin Expression Regulation of Expression and Secretion Adiponectin Clearance Adiponectin Receptors and Downstream Effectors Adiponectin Signaling Conclusions References
Adiponectin receptor 1
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Norwegian Psychomotor Physiotherapy (NPMP) has been an established treatment approach for more than 50 years, although mostly in the Scandinavian countries, and is usually applied to patients with widespread and long-lasting musculoskeletal pain and/or psychosomatic disorders. Few studies have been investigating outcome of NPMP and no randomized clinical trials (RCT) have been systematically tried out on individuals. This is a study protocol for a pragmatic, single blinded RCT, which will take place in a city of Norway. The participants will be block randomized either to receive NPMP or Cognitive Patient Education in combination with active individualized physiotherapy (COPE-PT). The intervention will reflect usual care and will be conducted in physiotherapy clinics by five experienced physiotherapists in each of the two treatment approaches. The findings of the present study may give an important contribution to our knowledge of the outcome of NPMP, on patients with long-lasting widespread musculoskeletal pain and/or pain located to the neck and shoulder region. The study has been registered with ClinicalTrials.gov (June 9 th 2015, NCT02482792).
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Sports medicine
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Abstract Aims: To study circulating levels and distribution of adiponectin multimers [low molecular weight (LMW)-, medium molecular weight (MMW)- and high molecular weight (HMW)-adiponectin] in preterm and full-term infants. Methods: Total serum adiponectin and its multimers were measured in 40 healthy infants at the age of one month and associations with anthropometric parameters [body weight and length, body mass index (BMI)], weight gain and metabolic indices (glucose, insulin) were examined. Twenty of the infants were born preterm (gestational age 33.2±1.6 weeks). Results: LMW-adiponectin level and its fractional ratio to total adiponectin were significantly higher in full-term than in preterm infants (P<0.001 and P<0.01, respectively), whereas, MMW-adiponectin level and its ratio were significantly lower (P=0.03 and P=0.01, respectively). HMW-adiponectin did not differ significantly between full-term and preterm infants and accounted for almost 60% of total adiponectin levels in both groups. HMW-adiponectin, but not MMW adiponectin or LMW adiponectin, correlated significantly with anthropometric measurements, similarly to total adiponectin; in addition, HMW adiponectin correlated significantly with weight gain. Conclusions: HMW adiponectin is the most prevalent form in infants. Circulating levels and distribution of MMW- and LMW-adiponectin differ between full-term and preterm infants, but the role of these adiponectin multimers needs to be studied further.
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In many studies, high-molecular-weight (HMW) adiponectin has been considered the active form of adiponectin. However, whether HMW adiponectin is a good surrogate marker for coronary artery disease still needs to be elucidated.We conducted a hospital-based cross-sectional study to examine the relationship between total, HMW or non-HMW adiponectin concentrations and coronary stenosis in 83 male patients and 138 male controls.Patients with coronary stenosis had significantly lower total adiponectin concentrations compared with controls. Non-HMW adiponectin concentrations in cases were significantly lower than the controls. However, there were no significant differences between cases and controls in HMW adiponectin concentrations. From the receiver operating characteristic (ROC) analysis, the area under the curve (AUC) for total and non-HMW adiponectin was significantly larger than that for HMW adiponectin concentrations. Of the three models, that for non-HMW adiponectin showed the largest AUC (total adiponectin 0.74, HMW adiponectin 0.54, and non-HMW adiponectin 0.79).Despite associations between total adiponectin levels and coronary stenosis, our data go against any apparent association between HMW adiponectin concentrations and coronary stenosis.
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Adiponectin은 지방세포에서 분비되는 아디포카인 중의 하나로서 에너지 대사, 인슐린 저항성, 심혈관계에 조절역할을 하는 것으로 밝혀지고 있다. Adiponectin 유전자는 염색체상에서 제2형 당뇨병 감수성과 연관된 것으로 확인된 3q27 부위에 위치하는데[4], adiponectin 유전자의 일부 유전자 다형성이 adiponectin 농도, 제2형 당뇨병, 비만과 연관되어 있음이 보고된 바 있으며, 그 중 대표적인 것이 T45G와 G276T이다. 따라서 본 연구에서는 adiponectin 유전자 다형성과 제2형 당뇨병 사이에 어떠한 연관성이 한국인에서도 있는지 알아보았다. 연구 결과 T45G 유전자 다형성은 제2형 당뇨병과 유의성을 가짐을 확인하였으나, G276T의 경우에는 유의적인 연관성을 보이지 않는 것으로 확인되었다. 이는 여러 인구 집단과 비교하였을 때에 T45G 유전자 다형성의 경우에는 한국인에서 제2형 당뇨병의 marker로 사용하는 것이 가능하다고 판단된다. Adiponectin은 이미 항염증반응, 항동맥경화 작용이 있다는 것이 알려져 있을 뿐만 아니라 제2형 당뇨병과도 관련이 있다고 보고되어 있으므로 adiponectin을 증가시킴으로써 제2형 당뇨병이나 비만 등의 치료 및 예방 효과를 보일 수 있을 것으로 보고 있다. 따라서 adiponectin의 분자 수준에서의 연구를 위해서 유전자 다형성과 제2형 당뇨병과의 연관성에 대한 연구는 필수적이라 할 수 있으며, adiponectin 유전자 다형성에 관한 본 연구결과의 임상적인 의의를 확실하게 확인하기 위하여서는 향후 대상 환자 수와 대조군을 더욱 늘리고 다양한 adiponectin 유전자 다형성을 후보로 하여 추가적인 연구를 할 필요가 있을 것으로 생각된다. Type 2-diabetes is a typical polygenic disease complex, for which several common risk alleles have been identified. Adiponectin, which modulates insulin resistance as well as glucose and lipid metabolism, has recently been associated with type 2-diabetes (T2DM). Therefore, we investigated the genotype for the T45G and G267T polymorphisms in adiponectin genes in the Korean population and compared genotypes of patients with those of a control group. 100 patients (63 male, 37 female), who previously underwent T2DM and 100 controls (36 male, 63 female) participated in this study. There was a strong association between T45G polymorphism in the adiponectin gene and T2DM. The present study shows that adiponectin T45G polymorphism may be associated with the pathogenesis of T2DM. Further studies with a larger population may be needed for the development of diagnostic methods at genetic levels such as DNA chip.
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An important link between adiponectin and hypertension has been proposed in clinical studies. In the circulation, adiponectin is predominantly present in multimeric complexes, of which high–molecular weight (HMW) adiponectin is thought to represent the biological active form. The authors investigated which role the different multimeric adiponectin isoforms play in context with hypertension as compared to total adiponectin levels. Fifty (19 normotensive/31 hypertensive) patients were included in the study. Total adiponectin and adiponectin multimers were determined by enzyme‐linked immunosorbent assay and western blot. The authors analyzed associations between adiponectin multimer levels and blood pressure. Total adiponectin concentrations were not significantly different between hypertensive and normotensive patients (6.8±2.3 vs 7.5±4.2 μg/mL). HMW adiponectin was significantly lower (P< .05) and low–molecular weight adiponectin was significantly higher ( P< .01) in hypertensive than in normotensive persons (3.8±1.7 vs 5.2±3.0 μg/mL and 0.9±0.5 vs 1.8±0.9, respectively). Low molecular weight was an independent predictor for the presence of hypertension (effect coefficient: 0.160–0.445; P< .001) in multivariate analyses. These results suggest that the composition of the molecular weight forms of adiponectin in hypertension are characterized by reduced HMW adiponectin, the proposed major active form of adiponectin, and increased low–molecular weight adiponectin. Moreover, the latter represents an independent predictor of prevalent hypertension, suggesting an association between adiponectin multimer composition and hypertension.
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Adiponectin is one of the adipocytokines that is derived from adipose tissue.It has anti-inflammatory,anti-diabetic,anti—atherogenic and insulin-sensitizing effects.Recent researches show Adiponectin is relational with chronic liver disease,In text,we describe adiponectin,source,adiponectin,structure,adiponectin,biological function and effect of adiponectin in chronic liver disease.
Chronic liver disease
Liver disease
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Objective To study the pathogenesis in type 2 diabetes(DM) retinopathy(DR)about adiponectin and tumor necrosis factor(TNF-α).Method Adiponectin and TNF-α were measured in the serum of 90 cases of type 2 diabetes patients and 40 healthy human by enzyme-linked immunosorbent assay(ELISA).The 90 patients were divided into non-DR(NDR) group,background-DR group(BDR) and proliferative-DR(PDR) grioup.Result ①The serum adiponectin and TNF-α levels in DM group were lower than in the control group(P0.05);② The levels of adiponectin and TNF-α in BDR group were less than in NDR group(P0.05);③The contents of adiponectin and TNF-α in PDR group were less than NDR group's(P0.01);④The contents of adiponectin and TNF-α in PDR group were less than BDR group(P0.05);⑤The gravity of DR were negatively correlated to the levels of adiponectin(r=-0.428,P0.01).Conclusion The reduction of adiponectin and TNF-α plays an important role in the pathogenesis of DM.The adiponectin and TNF-α may be involved in the occurrence and development of DR because the levels of blood adiponectin and TNF-α are more lower in type 2 diabetic retinopathy.
Pathogenesis
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