149Atypically fractionated radiation therapy and mitomycin C (MMC) in head and neck cancer
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ObjectiveTo probe the laws of the cross-adapting respons e induced by low dose radiation and low concentration mitomycin C.MethodsThe human lymphocytes,bone marrow cells of mice w ere treated by low dose X-ray or low concentration mitomycin C before treated b y high dose X-ray or high concentration mitomycin C.Some targets were observed,s uch as chromosome aberration of human lymphocytes,bone marrow cells of mice,micr onuclear(MN),sister chromatied exchange(SCE).ResultsThe targets of above all appeared cross-adapt res ponse.ConclusionCross-adapt response can be inducd by low dose radiation or by low concentration mitomycin C not only in vivo but also i n vitro.
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Purpose. To evaluate the efficacy and safety of topical mitomycin C (MMC) for conjunctival-corneal intraepithelial neoplasia (CCIN). Methods. One patient with primary CCIN received seven applications for 3 minutes of mitomycin C 0.02%, for 2 weeks, on alternative days. The size of the CCIN before and after the treatment and ophthalmic mitomycin C related complications were evaluated. Results. The lesion started to regress during the second month after the last application of mitomycin C, and by the third month it disappeared completely. The patient remains disease free after 36 months follow up. The complications of mitomycin C included a mild tearing and a slight conjunctival hyperemia that resolved 7 days after the end of the therapy. Conclusion. Multiple applications of mitomycin C could be an effective treatment for selected cases of CCIN.
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This article describes the first reported case of trans-conjunctival Preserflo microshunt erosion after revision surgery augmented with mitomycin C. Recommendations to avoid this complication include removal of original microshunt and limiting secondary application of mitomycin C.
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Sequence (biology)
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Objective:To investigate the anti tumor effects of cooperation of cinobufacine injection with mitomycin C in vitro.Method: The cytotoxicity of mitomycin C cooperated with cinobufacine injection against established hepato cell lines(SMMC 7721,BEL 7402 and L 02 cell)was determined by MTT assays. Mitomycin C, cinobufacine injection were used separately as control. Result: Cooperation of cinobufacine injection with mitomycin C showed much more better anti tumor effect than the drugs used separately, but do not significantly enhance the growth inhibitory rate of normal hepatic cell lines. Conclusion: Cooperation of cinobufacine injection with mitomycin C has better anti tumor effect than the drugs used separately,meanwhile it do not enhance cytotoxicity to normal hepatic cell line, showing its feasibility and validity in hepatocellular carcinoma curing.
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Hepatic carcinoma
MTT assay
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Mucositis
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Rabbits with peritoneal carcinomatosis induced by VX2 carcinoma were used as an experimental model to study a new dosage form of mitomycin C, MMC-CH, comprising activated carbon adsorbing mitomycin C. Rabbits revived an intraperitoneal injection of mitomycin C (1 mg/kg in the form of MMC-CH or 0.185 mg/kg in the form of mitomycin C solution). The two doses were equal in toxicity. MMC-CH extended survival time measured in days to 139% as compared to mitomycin C solution. Autopsy findings showed peritoneal carcinomatosis to be much less developed with MMC-CH than with mitomycin C solution. Hematological and blood biochemical analyses showed no remarkable abnormality.
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Carcinosis
Peritoneal cavity
Experimental animal
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