One‐Step Synthesis of 2‐Aryl‐4,5‐diphenylimidazoles Under Microwave Irradiation
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Abstract A series of 2‐aryl‐4,5‐diphenylimidazoles were synthesized by a one‐step condensation reaction of benzil, aromatic aldehyde, and ammonium acetate in acetic acid under microwave irradiation. The reactions were completed in 4–11 min with good yields and easy workup.Keywords:
Benzil
Condensation reaction
A simple and highly efficient approach for the synthesis of γ-Benzopyranones and 3,4- Dihydropyrimidin-2(1H)-ones/thiones using ammonium acetate as a promoter under thermal as well as microwave irradiation using solvent-free conditions has been demonstrated. Keywords: γ, 3, 4-dihydropyrimidin-2(1H)-ones/thiones, ammonium acetate, solventfree synthesis, promoter.
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Abstract A series of 2‐aryl‐4,5‐diphenylimidazoles were synthesized by a one‐step condensation reaction of benzil, aromatic aldehyde, and ammonium acetate in acetic acid under microwave irradiation. The reactions were completed in 4–11 min with good yields and easy workup.
Benzil
Condensation reaction
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Nano TiO2 supported on SiO2 (Nano TiO2@SiO2) as a solid Lewis acid, was described to be an effective and reusable catalyst for one-pot three-component reaction of benzil, aryl aldehydes and ammonium acetate for the synthesis 2-aryl-4,5-diphenyl1H-imdazoles synthesis. To explore the high efficacy of the catalytic system the four -component cyclization of benzil, aryl aldehydes, ammonium acetate and anilines has also been accomplished successfully to obtain their 1,2 -diaryl-4,5-diphenyl-1Himidazole adducts. A plausible mechanism has also been expressed. The catalyst has been recovered and its reusability confirmed in 4 runs. High yields, simple operation, easy -work procedure, mild reaction conditions in addition with the reusability are some advantages of this protocol.
Benzil
Reusability
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Abstract Natural scolecite has been found as an effective catalyst for the one-pot synthesis of 2,4,5-triarylimidazole derivatives via a three component reaction using benzil or benzoin, aldehydes and ammonium acetate. This method provides several advantages such as being environmentally benign, reusable, possessing high yields with increased variations of the substituents in the product and preparative simplicity.
Benzil
Benzoin
Simplicity
Component (thermodynamics)
Natural product
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Starting from 4-aminohippuric acid (AHA), two novel series of heterocyclic compounds of pharmaceutical interest have been synthesised by one-pot, multicomponent reactions under microwave conditions. Reaction of AHA with various aldehydes and benzil in (1:1) EtOH/acetic acid in the presence of ammonium acetate yielded 1,2,3,5-tetra-arylated imidazole derivatives, whereas a solvent-free reaction of AHA with various aldehydes and dimedone (2 equiv.) in the presence of p-TSA yielded 4,9-diarylated 1,8-dioxo-decahydroacridine derivatives. These reactions produced good yields in short reaction times with an easy work-up, and purification of products was achieved by simple recrystallisation.
Benzil
Imidazole
Dimedone
Benzimidazole
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Abstract The simple procedure allows a one‐pot cyclocondensation of benzil (I) with aromatic aldehydes and anilines or ammonium acetate to give tetra‐ or trisubstituted imidazoles.
Benzil
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Abstract The multicomponent cyclocondensation of benzil with aromatic aldehydes, an amine and ammonium acetate (or ammonium acetate alone) is efficiently catalyzed by SiO 2 ‐supported Wells—Dawson heteropolyacid to give the polysubstituted imidazole derivatives (IV) and (VI) in high yields.
Benzil
Imidazole
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Benzil
Trifluoromethanesulfonate
Ytterbium
Component (thermodynamics)
One-pot synthesis
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Fifteen substituted 2,4,5-triaryl-1H-imidazoles are synthesized by three-component and one-pot reaction of aromatic aldehydes,benzil and ammonium acetate under microwave irradiation,solvent and catalyst-free conditions.The products are identified by IR,1HNMR,13CNMR and MS.The method is in accordance with the requirement of green chemistry.
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