The Auckland calcium study: 5-year post-trial follow-up
27
Citation
17
Reference
10
Related Paper
Citation Trend
Keywords:
Discontinuation
A self-administrated questionnaire was performed to clarify the actual circumstances of community-based screening for osteoporosis. The results revealed that only 25 percent of communities performed follow-up of high-risk participants, representing a disappointing result for assessing evidence of the benefits of measuring bone mineral density in preventing osteoporosis. Secondly, a review of the literature was performed to clarify the benefits of measuring bone mineral density in preventing osteoporosis. The review revealed that increased measurements could predict fractures among elderly and peri- and postmenopausal women, and elderly men.
Cite
Citations (0)
Background: Reasons for treatment discontinuation are important not only to understand the benefit and risk profile of experimental treatments, but also to help choose appropriate strategies to handle intercurrent events in defining estimands. The current case report form (CRF) commonly in use mixes the underlying reasons for treatment discontinuation and who makes the decision for treatment discontinuation, often resulting in an inaccurate collection of reasons for treatment discontinuation. Methods and results: We systematically reviewed and analyzed treatment discontinuation data from nine phase 2 and phase 3 studies for insulin peglispro. A total of 857 participants with treatment discontinuation were included in the analysis. Our review suggested that, due to the vague multiple-choice options for treatment discontinuation present in the CRF, different reasons were sometimes recorded for the same underlying reason for treatment discontinuation. Based on our review and analysis, we suggest an intermediate solution and a more systematic way to improve the current CRF for treatment discontinuations. Conclusion: This research provides insight and directions on how to optimize the CRF for recording treatment discontinuation. Further work needs to be done to build the learning into Clinical Data Interchange Standards Consortium standards.
Discontinuation
Cite
Citations (0)
Discontinuation
Unintended Pregnancy
Cite
Citations (6)
This paper addresses current issues associated with medication discontinuation in panic disorder, with specific focus on one of the most frequently used medication classes for this indication, the benzodiazepines. The majority of patients, when slowly tapered, are able to discontinue the benzodiazepines without a great deal of difficulty, particularly after short-term therapy. Patients treated with long-term therapy at high therapeutic doses may experience greater difficulty with discontinuation. If patients are adequately prepared and if discontinuation is conducted slowly and gradually, discontinuation symptoms, if they occur, are transient, mild to moderate, and generally tolerable. However, return of the original condition (relapse) during discontinuation can greatly complicate clinical management.
Discontinuation
Cite
Citations (37)
Discontinuation of a crime can be divided into discontinuation of preparation of a crime, discontinuation of starting a crime,discontinuation of acting a crime and discontinuation of accomplished crime,negative and positive discontinuation,common discontinuation and quasi- discontinuation,damaged and non-damaged discontinuation and etc.Redefinition of the concepts of various discontinuation of a crime is helpful to the determination in judicial practice.
Discontinuation
Cite
Citations (0)
The present research reports some results concerning the discontinuation of a long-term treatment with lithium in two groups of bipolar patients, BPI and BPII. The aim of the research is the evaluation of the causes leading to the discontinuation of the treatment and its effects. In all subjects the treatment, not combined with other medications, was effective for at least two years before discontinuation. The results show a percentage of recurrences similar to that reported by other Authors, with significant differences that point out a greater risk of recurrences after an abrupt discontinuation. The hypotheses concerning early recurrences are discussed, taking into account the different features of the recurrences in the two groups.
Discontinuation
Cite
Citations (1)
There is concern that bluish skin discoloration associated with ezogabine treatment could be permanent. We present a case of ezogabine-induced skin discoloration that resolved completely after discontinuation. A 55-year-old woman started ezogabine 400 mg three times a day at age 41. Bluish pigmentation over the toe nails, finger nails, around eyes and over and around lips was first noted after 5 years of treatment. Ezogabine was discontinued eight years after initiation. Skin discoloration improved within 6 months and completely resolved within 6 years of discontinuation. This case suggests that ezogabine-induced discoloration is reversible after discontinuation of treatment.
Discontinuation
Cite
Citations (19)
OBJECTIVE To understand osteoporosis and bone mineral density measurement of middle-aged and aged people in Huairou of Beijing, put forward the prevention measures. METHODS Used Metriscan dual energy X-ray absorptiometry to detect bone mineral density in 894 cases, relationship between bone mineral density measurement and T-Score score (T), the prevalence of osteoporosis. RESULTS Every 10 years as a age period, a total of five age periods, age increased while bone mineral density, T value gradually declined, there were significant differences in bone mineral density value, T value in each age group (P﹤0.05). The bone mineral density and T value in each group were different between genders (P﹤0.05). (2) In 40-49 years, 50-59 years, 60-69 years, and 70-79 years, and 80 years groups, male osteoporosis prevalence was 2.31%, 4.76%, 17.11%, 33.33%、 64.29%, and female 3.31%, 11.97%, 35.56%, 61.54%, 75.00%. Female osteoporosis prevalence was higher than male. Older than 50 years, differences in prevalence were found between genders (P﹤0.05). CONCLUSION Determination of bone density contributes to the early detection of osteoporosis, osteoporosis prevalence of elderly in Huairou the increases with increasing age. Women have lower bone density and their osteoporosis prevalence is more serious, who is the main controlled target.
Dual energy
Dual-Energy X-ray Absorptiometry
Cite
Citations (0)