The radical scavenger edaravone counteracts diabetes in multiple low-dose streptozotocin-treated mice
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Edaravone
Scavenger
Free radical scavenger
Free radicals play major roles in the pathogenesis of many diseases, including neurologic diseases, making them an attractive target for therapeutic intervention. Several free radical scavengers have been developed, and some have progressed to clinical trials for the treatment of ischemic stroke. One such scavenger, edaravone is currently used to treat patients who present within 24 h of an attack. Edaravone can diffuse into many affected organs. Edaravone also exerts protective effects against brain and spinal cord injuries. Beyond its direct free radical scavenging effect, edaravone has anti-apoptotic and anti-inflammatory effects in various diseases. Here, we critically review the literature on experimental animal model and clinical studies of edaravone efficacy, and examine whether it should be considered a candidate for worldwide development. Edaravone has proven safe during 10 years of use as a free radical scavenger to treat ischemic stroke. In addition to ischemic stroke treatment, animal data suggest that edaravone may be an effective treatment option for several neurologic diseases, but additional clinical trials are necessary to verify its efficacy.
Edaravone
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Objective To explore the effect of free radical scavenger on the serum levels of endothelin-1 (ET-1) and interleukin-1 β (IL-1β) after the surgery and its meanings in the patients with cranial bases tumors.Methods Sixty-four patients with cranial bases tumors were randomly divided into both the routine treatment (not treated by free radical scavenger) and edaravone treatment groups.Thirty-two patients with cerebral convex lesions,who did not received free radical scavenger treatment,served as control group.Edaravone treatment included that the operated areas were irrigated with the fluid containing edaravone in the operation and the edaravone was injected into the peripheral veins after the operation.The serum levels of ET-1 and IL-1β were determined before and after the operation in all the patients.Results The serum levels of ET-1 and IL-1s levels were significantly higher in the routine treatment group than those in the control group after the operation (P0.05),they reached a peak 5～7 days after the operation,and then decreased gradually.The postoperative serum levels of ET-1 and IL-1β were significantly lower in edaravone treatment group than those in the routine treatment group (P0.05),but they were significantly higher than those in the control group (P0.05).Conclusions The increase in the serum levels of ET-1 and IL-1β after the operation may be decreased by free radical scavenger treatment in the patients with cranial bases tumors.It is suggested that the free radical scavenger may be of the protective effect on the cerebral vessels because the increase in the serum levels of ET-1 and IL-βmay be related to the cerebral vasospasm after the operation in the patients with cranial bases tumors.
Edaravone
Free radical scavenger
Scavenger
Radical surgery
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Edaravone is a free radical scavenger that was at first approved in the world. Edaravone has the therapeutic effect on ischemia reperfusion injury, nerve cells apoptosis, apomorphosis and so on by scavenging free radicals and preserving endoplasmic reticulum dysfunction, et al. Combining edaravone with other drugs to treat cerebral infarction, the effect is more effective. In addition, edaravone can protect the liver by scavenging free radicals and may have application values to many kinds of diseases. Edaravone is a free radical scavenger with a brilliantp erspectivei n clinic.
Edaravone
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Edaravone,a free radical scavenger,has been used for the treatment of acute cerebral ischemic stroke. Recent researches show that the pharmacological effect of edaravone may involve many organs and its clinical application is not limited to ischemic stroke. This article reviewed the pharmacological progress in the protective effects of edaravone on different organ injuries( brain,heart,liver,lung, etc.) in order to provide evidence for the novel clinical applications of edaravone in future.
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Edaravone
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Free radical scavenger
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Objective To observe the clinical efficacy of free radical scavenger edaravone on cerebral hemorrhage.Methods Thirty-six cerebral hemorrhage patients were randomly selected and assigned to treatment group and control group.Edaravone was added to treat on the patients of treatment group respectively.ESS and ADL were adoped to evaluate the efficacy of edaravone on 1,2,4 week after treatment.Results There were significant differences between treatment group and control group on 1,2,4 weeks after treatment.Conclusion Free radical scavenger edaravone can advanced the recovery of neural function and activity of daily living.It is a effective and safe drug to the treatment of cerebral hemorrhage.
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Objective. To investigate the efficacy of edaravone, a novel free radical scavenger, on preventing steroid-induced osteonecrosis (ON) in a rabbit model.
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Scavenger Receptor
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Edaravone
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Edaravone, a novel potent free radical scavenger for acute ischemic stroke：From laboratory to clinic
Free radical plays a key role in the process of cerebral ischemic injury. It aggravates cell membrane damage through the peroxidation of unsaturated fatty acids, and then results in neuronal death and brain edema. Edaravone, a novel potent free radical scavenger, exerts its neuroprotective effect by inhibiting endothelial injury in cerebral ischemic areas and relieving neuronal damage. It also reduces thrombolytic therapy-induced brain edema and bleeding events after reperfusion. Clinical experiences suggest that the therapeutic time window of edaravone is very wide, and when it combines with thrombolytic therapy, it may reduce stroke mortality and promote the recovery of neurological deficit. This article reviews the course of development of edaravone from laboratory to clinical stage.
Key words:
edaravone; ischernic stroke; neuroprotection; antioxidant; free radical scavenger
Edaravone
Free radical scavenger
Stroke
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