Molecular analysis of intrafamiliar transmission of Moraxella catarrhalis
Hiroshi WatanabeKazuhiko HoshinoRinya SugitaNorichika AsohHeinner GuioLiang QinChiharu KajiKiwao WatanabeKazunori OishiTsuyoshi Nagatake
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Moraxella (Branhamella) catarrhalis
Moraxella catarrhalis in responsible for a considerable number of bronchopulmonary infections in adults, as well as otitis media and sinusitis in children. Many strains of Moraxella catarrhalis produce beta-lactamase and are resistant to many beta-lactam antibiotics. When Moraxella catarrhalis in considered to be a causative organism, the choice for an empiric antimicrobial therapy should be beta-lactamase-resistant antibiotics.
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We compared the distribution of organisms in the nasopharynx and the middle ear fluid in 164 episodes of acute otitis media in children 6-35 months of age. In contrast to Streptococcus pneumoniae and Haemophilus influenzae , Moraxella catarrhalis is isolated from the middle ear in only 11% of episodes with nasopharyngeal colonization with this organism.
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Journal Article Epidemiology of Moraxella catarrhalis in Children during the First 2 Years of Life: Relationship to Otitis Media Get access Howard Faden, Howard Faden Reprints or correspondence: Dr. Howard Faden, Division of Infectious Diseases, Children's Hospital of Buffalo, 219 Bryant St., Buffalo, NY 14222. Search for other works by this author on: Oxford Academic PubMed Google Scholar Yasuaki Harabuchi, Yasuaki Harabuchi Search for other works by this author on: Oxford Academic PubMed Google Scholar Jong J. Hong, Jong J. Hong Search for other works by this author on: Oxford Academic PubMed Google Scholar Tonawanda/Williamsville Pediatrics Tonawanda/Williamsville Pediatrics Search for other works by this author on: Oxford Academic PubMed Google Scholar The Journal of Infectious Diseases, Volume 169, Issue 6, June 1994, Pages 1312–1317, https://doi.org/10.1093/infdis/169.6.1312 Published: 01 June 1994 Article history Received: 26 July 1993 Revision received: 24 January 1994 Published: 01 June 1994
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Objective To establish a novel method for rapid identification and drug resistance of Moraxella catarrhalis, Different sourses of blood and the formula of chocklate agars were detected the Growth Index(GI). Methods Moraxella catarrhalis from specimens contaminated by microbial flora were isolated with a choclate agar with 50 mg/L vancomycin (CHOC-V) method. Nine media were inoculated,on which GI were calculated and compared. beta-Lactamase were determined by nitrocefin slip method. Results 228 strains of Moraxella catarrhalis and 203 strains of recent limbus bacteria were examined. The sensitivity of this method was 100%,and the specificity was 100%. The GI of Moraxella catarrhalis on chocklate agars and blood agars was higher than that of the BCA, NUA, MHA ( P0.05). beta-Lactamase positive rate in Moraxella catarrhalis was 93.0%. The MIC 50 and MIC 90 of PIPC/SBT and PIPC/TAZ against Moraxella catarrhalis were 8 times lower then PIPC.The MIC 50 and MIC 90 of AMP/SBT against Moraxella catarrhalis were 8 times lower then AMP. Conclusions This method is rapid, accurate and simple for identifying Moraxella catarrhalis. PIPC/SBT,CFP/SBT,PIPC/TAZ,AMP/SBT,IPM/CST showed high activity against Moraxella catarrhalis of beta-Lactamase positive.
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Taxonomic Review: Family Moraxellaceae
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Acinetobacter
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Moraxella
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Moraxella nonliquefaciens
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Moraxella lacunata
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Moraxella osloensis
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Minor Species
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Animal-Associated Species
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Moraxella (Branhamella) Catarrhalis
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Acknowledgments
Keywords:
Acinetobacter and Moraxella;
genus Moraxella-several taxonomic revisions;
Acinetobacters-saprophytic and ubiquitous;
virulence and pathogenic factors;
management, therapeutic options and susceptibility testing;
Moraxella nonliquefaciens-commonly isolated species of genus;
M. catarrhalis-gram-negative diplococci;
M. catarrhalis-susceptible to penicillin and β-lactamase negative
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Journal Article A membrane-bound precursor β-lactamase in strains of Moraxella catarrhalis and Moraxella nonliquefaciens that produce peripiasmic BRO-1 and BRO-2 β-lactamases Get access Vincent A. Steingrube, Vincent A. Steingrube aThe University of Texas Health Center at Tyler, Department of MicrobiologyP.O. Box 2003, Tyler, TX 75710 Search for other works by this author on: Oxford Academic PubMed Google Scholar Richard J. Wallace, Richard J. Wallace aThe University of Texas Health Center at Tyler, Department of MicrobiologyP.O. Box 2003, Tyler, TX 75710 Search for other works by this author on: Oxford Academic PubMed Google Scholar Danielle Beaulieu Danielle Beaulieu aThe University of Texas Health Center at Tyler, Department of MicrobiologyP.O. Box 2003, Tyler, TX 75710 Search for other works by this author on: Oxford Academic PubMed Google Scholar Journal of Antimicrobial Chemotherapy, Volume 31, Issue 2, February 1993, Pages 237–244, https://doi.org/10.1093/jac/31.2.237 Published: 01 February 1993 Article history Received: 23 July 1992 Accepted: 20 October 1992 Published: 01 February 1993
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ABSTRACT Outer membrane protein E (OMP E) is a 50-kDa protein of Moraxella catarrhalis which has several features that suggest that the protein may be an effective vaccine antigen. To assess the conservation of OMP E among strains of M. catarrhalis, 22 isolates were studied with eight monoclonal antibodies which recognize epitopes on different regions of the protein. Eighteen of 22 strains were reactive with all eight antibodies. The sequences of ompE from 16 strains of M. catarrhalis were determined, including the 4 strains which were nonreactive with selected monoclonal antibodies. Analysis of sequences indicate a high degree of conservation among strains, with sequence differences clustered in limited regions of the gene. To assess the stability of ompE during colonization of the human respiratory tract, the sequences of ompE of isolates collected from patients colonized with the same strain for 3 to 9 months were determined. The sequences remained unchanged. These results indicate that OMP E is highly conserved among strains of M. catarrhalis, and preliminary studies indicate that the gene which encodes OMP E remains stable during colonization of the human respiratory tract.
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Two closely related beta-lactamases, BRO-1 and BRO-2 (formerly called Ravasio and 1908), are found in Moraxella (Branhamella) catarrhalis. We screened strains of B. catarrhalis recovered in the United States since 1952 and identified the first beta-lactamase-positive isolate in August 1976. The prevalence of the enzymes among 394 clinical isolates from one Texas hospital has averaged 75% since testing began in 1983. Screening of isolates of Moraxella subgenus Moraxella revealed the BRO enzymes in two other human respiratory tract species, M. lacunata and M. nonliquefaciens, beginning in 1978. A different beta-lactamase with a pI of 6.4 predominated in other species of subgenus Moraxella. BRO-2 had a different isoelectric focusing pattern and was produced in lesser amounts than BRO-1, but the two enzymes were indistinguishable by substrate or inhibitor profile. BRO enzymes from B. catarrhalis, M. nonliquefaciens, and M. lacunata could be transferred by conjugation and, for B. catarrhalis, also by transformation to B. catarrhalis. Plasmid bands were demonstrated in 90% of M. nonliquefaciens and in one previously reported strain of B. catarrhalis, but no change in plasmid profiles was seen in beta-lactamase-positive recombinants, supporting previous studies that suggested the beta-lactamase genes are chromosomal.
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