Abstract A25: Variations of human papillomavirus type 16 in cervical, lung, and skin cancers in Sichuan, China
Jian ZhangTao WangMin HanZhihui YangMin ZhangLunxu LiuBin ZhouYue ChenQiannan HouYanyun WangTing LaiLin ZhangHuaizhong HuMingrong Xi
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Abstract Human papillomavirus (HPV) is closely related with many kinds of cancers such as cervical, lung, and skin cancers, etc. HPV 16 showed intratypic variations that were known to differ in oncogenic potential and geographic distribution. This study was designed to analyze sequence variants in oncogenes E6, E7 and L1 of HPV 16 in cervical, lung, and skin cancers in Sichuan, China. Materials from 138 non-malignant controls, 122 cervical cancer patients, 104 lung cancer patients and 104 skin cancer patients were analyzed by PCR and direct sequencing. The infection rates of HPV 16 in cervical, lung, skin cancers were respectively 68.9%, 17.3%, 5.8%. The Asian prototype was the most prevalent variant in cervical cancer in Sichuan (40%). Compared with that detected in cervical cancer, lung and skin cancers showed more monotonous variations, but several mutations on L1 genes existed only in lung or skin cancers such as G6818C, C7011A, and C7017A. Citation Information: Clin Cancer Res 2010;16(14 Suppl):A25.Knowledge of the risk factors for cervical cancer (CC) and the benefits of cervical cancer prevention motivates women to participate in preventive screening. However, several studies indicate that thereis a significant lack of knowledge about the human papillomavirus (HPV) around the world. This study examines the level of knowledge about the prevention of HPV and cervical cancer in the contextof socio-demographic and behavioral characteristics of women in Uzbekistan.Key words: questioning, cervical cancer, Human Papillomavirus, prevention
Cancer Prevention
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Background While HPV infection is the main cause of cervical cancer, genetic susceptibility to HPV infection is not well understood. Tumor necrosis factor alpha (TNF-alpha), involved in the defense against HPV infection, plays an important role in cervical cancer progression and regression. The aim of this study was to investigate the relationship between the TNF-alpha rs1800629 polymorphism and risk of HPV infection or cervical cancer. Methods Three groups were involved in this study of Chinese women. Group 1 consisted of 285 high risk HPV positive cervical cancer patients, Group 2, 225 high risk HPV positive patients without cervical cancer, and Group 3, 318 HPV negative women with no cervical cancer. Blood samples were obtained from all patients and genotyped by PCR-RLFP. Fifty randomly selected samples were further sequenced. Results The allele and genotype distributions of the TNF-alpha rs1800629 polymorphism were not significantly different between each of the groups (P>0.05). There are no significant relationship between rs1800629 polymorphism and high risk HPV infection (OR = 0.649, 95% CI: 0.253–1.670, P = 0.371), cervical cancer (OR = 0.993, 95% CI: 0.376–2.618, P = 0.988), or cervical cancer with HPV infection (OR = 0.663, 95% CI: 0.250–1.758, P = 0.409). Conclusions We demonstrated that there is no association between TNF rs1800629 polymorphism and the HPV infection, or cervical cancer with HPV infection.
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Objective: To detect the expression of Her-2 protein in cervical carcinoma,and explore the related clinical significance.Methods: A total of 60 cases with cervical cancer resection from 2008 January to 2010 January were collected,and were divided into three stages according to TNM stages: 18 cases at Ⅰstage,II 29 cases,Ⅲ13 cases.Normal cervical epithelial tissues in 20 cases were selected as control group.Expression of Her-2 protein was detected in cervical tissue by immunohistochemistry.Results: Her-2 protein was expressed in cervical carcinoma tissues and normal tissues,the positive rate in cervical cancer tissues was 68.3%,significantly higher than those in normal cervical tissue of 20%(P0.01).Positive rates of Her-2 protein at Ⅰ,II,III clinical staging were 44.4%,75.7%,84.6%,there was significant difference in positive rate between different clinical stages(P0.05),with the increase of clinical stage of Her-2 protein expression,the rate of the corresponding was increased(P0.05).Conclusions: Her-2 protein plays a certain role in the development of cervical cancer,and can be used for tumor grading and prognosis.It may also be a potential therapeutic target in cervical cancer,with significant clinical value.
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Objective:To study the prevention,treatment and early detection of carcinoma of cervical stump.Methods:To review data of two cases of cervical stump cancer and related literature.Results:Its treatment is the same as the general cervical cancer.effect of surgical treatment of early carcinoma of cervical stump is the same with the cervical cancer in general.Conclusion:Carcinoma of cervical stump is less common.Its incidence rate is related to the number of cases of hysterectomy follow-up and residual cervical detection of carcinoma of cervical stump are important.
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Human papillomavirus is recognised as the main cause of cervical cancer. Vaccines to protect against specific HPV types have been developed and a national HPV vaccination programme is due to begin in the UK in September 2008. Girls aged 12 to 13 years of age will be offered one of the vaccines, Cervarix, and it is hoped that it will offer them protection against over 70% of cervical cancer.
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Carcinoma in situ
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Objective:To investigate the expression of Bcl-2,Bag-1 in the pathogenesis and progression of cervical cancer and their relationship.Methods:S-P immunohistochemical analysis was performed in 36 cervical carcinoma and 64 cases of CIN.Results:Overexpression of Bcl-2 and Bag-1 protein in CIN and cervical cancer was remarkably higher than that in the control(P0.01),whereas the difference between CIN and cervical cancer was not significant(P0.05).Bcl-2 protein expression was positive correlation with Bag-1 protein expression in cervical carcinoma.Conclusion:Bag-1 and Bcl-2 overexpression might play an important role in the pathogenesis and development of cervical cancer.The overexpressions of Bcl-2 and Bag-1 are the early event of cervical carcinogenesis which are associated with the development of cervical carcinoma.Bcl-2 and Bag-1 protein in the development of cervical carcinoma enhance each other.
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P53 protein
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Infection with human papillomavirus (HPV) is the first necessary cause for cervical cancer development. Although cervical cancer can be prevented and treated if detected early enough, it is the second biggest cause of female cancer mortality worldwide. Early detection of precursor cervical lesions by screening methods based on cytological and/or HPV testing should be encouraged because it offers protection against invasive cervical cancer. This review discusses the essential issues concerning cervical cancer and provides future prospectives.
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Objective To analyze the relationship between multiple human papillomavirus (HPV) infections and cervical dysplasia. Methods The cervical samples of 591 women were obtained from August 2004 to August 2006 in Haifeng County and differentiated for HPV subtypes. Results The HPV infection rate was 44.6%. There double infections of HPV 52/58 and HPV 16/18 were common. The multiple infection rates were increased along with the severity of cervical dysplasia (except for caner), and are significant higher than the normal group (P0.01). Conclusion Multiple HPV infection is associated with the development of cervical neoplasia.
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