Cocaine self-administration differentially alters mRNA expression of striatal peptides

Using a combination of radioactive and non-radioactive in situ hybridization, the μ opioid receptor mRNA was localized in enkephalin as well as dynorphin neurones of the rat striatum. The proportion of enkephalin neurones showing co-localized μ opioid receptor mRNA was dependent on the rostrocaudal level (17–39% in rostral/ intermediate levels vs 0.4–5% caudally) but did not differ between striatal subregions. For dynorphin neurones the reverse was true, with consistently higher levels of co-localization in the caudate-putamen (56–77%) than the nucleus accumbens (15–43%), but no differences along the rostrocaudal axis. Furthermore, the degree of enkephalin/μ co-localization was significantly lower than that of dynorphin/μ. These results suggest a finegrained topological differentiation of μ receptor modulation of striatal opioid systems.

Dynorphin

Dynorphin A

Ventral striatum

10.1097/00001756-199609020-00011

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Citations (45)

Effects of single and repeated morphine administration on the prodynorphin, proenkephalin and dopamine D2 receptor gene expression in the mouse brain

Neuropeptides (1997)

Jadwiga Turchan Władysław Lasoń Bogusława Budziszewska Barbara Przewłocka

Dynorphin

Proenkephalin

Ventral striatum

10.1016/s0143-4179(97)90015-9

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Citations (64)

Effects of repeated psychostimulant administration on the prodynorphin system activity and kappa opioid receptor density in the rat brain

Neuroscience (1998)

Jadwiga Turchan Barbara Przewłocka Władysław Lasoń Ryszard Przewłocki

Dynorphin

κ-opioid receptor

Mesolimbic pathway

10.1016/s0306-4522(97)00639-8

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Citations (96)

Colocalization of CART peptide with prodynorphin and dopamine D1 receptors in the rat nucleus accumbens

Neuropeptides (2006)

George W. Hubert Michael J. Kuhar

Dynorphin

Cart

Colocalization

Ventral striatum

Putamen

10.1016/j.npep.2006.09.001

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Citations (37)

A rostrocaudal gradient in the synthesis of enkephalin in nucleus accumbens

Neuroreport (1992)

Pieter Voorn Gerrit J. Docter

A subpopulation of projection neurons in the nucleus accumbens uses the neuropeptide enkephalin as a neurotransmitter. The synthesis of enkephalin in striatal neurons is regulated by dopaminergic inputs. In the present study quantitative in situ hybridization histochemistry was used to examine the effects of unilateral 6-hydroxydopamine lesions of the ascending dopaminergic fibres on levels of enkephalin mRNA in subregions of the nucleus accumbens. It was found that the levels of enkephalin mRNA were increased throughout the nucleus after the lesion. However, the increase appeared to be much higher in rostral parts of the nucleus than in caudal parts, indicating regional differences in the effects of blockade of the dopaminergic neurotransmission. Possible causative factors for these differences are discussed.

Dynorphin

Met-enkephalin

10.1097/00001756-199202000-00010

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Citations (26)

Met-enkephalin-like and dynorphin-like immunoreactivities of the basal ganglia of the cat

Life Sciences (1983)

Marie‐Françoise Chesselet Ann M. Graybiel

Dynorphin

Met-enkephalin

Opiate

Basal (medicine)