An oral controlled release matrix pellet formulation containing nanocrystalline ketoprofen
G.J VergoteChris VervaetIsabel Van DriesscheSerge HosteStefaan C. De SmedtJ. DemeesterRahul JainShaun RuddyJean Paul Remon
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Ketoprofen
Pellet
Maltodextrin
Pellet
Filler (materials)
Microcrystalline
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Spray drying is the highly accepted and widely followed technique for encapsulation of bioactive compounds. The efficiency of encapsulation is highly dependent on the encapsulating agent. This experiment was conducted in a view to check the suitability of different levels of maltodextrin as an encapsulating agent in spray drying of avocado powder. Spray drying at different maltodextrin levels i.e., 5%, 10%, 15%, and 20% were performed to evaluate the physical attributes of spray-dried avocado powder. Results showed that higher levels of maltodextrin favoured in achieving stability by minimizing the residual moisture levels and water Activity. Moreover, it significantly induced the free-flowing attributes of spray-dried powder.
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Persea
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Abstract The powder mixture of gum arabic and maltodextrin was produced by spray drying. The inlet air temperature of spray dryer was varied from 160 °C to 260 °C and the maltodextrin content was varied from 0 to 50 % in the feed solution with the concentration of 42.5 % (w/v) total solids by weight. The properties of the finished product were characterized to examine the impact of changes in these operating parameters. The results showed that: the inlet air temperature had a stronger influence on the properties of finished product than the MD/GA ratio, whereas the feed rate was more clearly affected by the MD/GA ratio. Two optimal parameters obtained include MD/GA ratio equal to 0.615 and the inlet air temperature of spray dryer Te = 258 °C.
Maltodextrin
Gum arabic
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Spray-dried redispersible transcinnamaldehyde (TC)-in-water emulsions were prepared in order to preserve its antibacterial activity; 5% (w/w) TC emulsions were first obtained with a rotor-stator homogeniser in the presence of either soybean lecithin or sodium caseinate as emulsifiers. These emulsions were mixed with a 30% (w/w) maltodextrin solution before feeding a spray-dryer. The antibacterial activity of TC alone, TC emulsions with and without maltodextrin before and after spray-drying were assayed by monitoring the growth at 30 °C of Listeria innocua in their presence and in their absence (control). Whatever the emulsifier used, antilisterial activity of TC was increased following its emulsification. However, reconstituted spray-dried emulsions stabilised by sodium caseinate had a higher antibacterial activity suggesting that they better resisted to spray-drying. This was consistent with observation that microencapsulation efficiencies were 27.6% and 78.7% for emulsions stabilised by lecithin and sodium caseinate, respectively.
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Cornsilk is maize waste containing phenolic compounds. In this study, freeze-drying, spray-drying, and microwave-drying techniques were evaluated for the encapsulation of cornsilk’s phenolic compounds using maltodextrin as wall material. The results of antioxidant properties showed that freeze-drying was more efficient than microwave-drying and spray-drying techniques. The highest recovery of phenolic compounds was obtained with freeze-drying. The microstructure, DSC, and FTIR data showed that the encapsulation process was effective, and freeze-drying was the best drying technique. The physical properties of the microparticles greatly changed with the drying techniques. This study revealed that the phenolic compounds of the cornsilk extract can be successfully encapsulated and valorized.
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Abstract It is a common practice for the medicinal herbs which contain valuable bioactive compounds to be preserved by converting it into dry powder through various drying technology such as oven, freeze and spray drying. However, the number of study for the production of Centella asiatica L. ( CAL ) powder through spray drying process has been very limited and most of the work only focused on the chemical properties of the herbs. Therefore, the purpose of this study is to investigate the feasibility of spray dried CAL powder at different maltodextrin concentrations (0–10 %w/w) and inlet air temperatures (130–170°C). The spray dried CAL powders were analysed for the percentage of yield, outlet temperature, appearance and moisture content while the reconstituted powders were assessed for its colour and radical scavenging activity (RSA). The findings showed that the increased of maltodextrin concentration resulted in higher percentage of yield (12.60 ± 0.14 to 51.05 ± 1.68 g), decreased in the moisture content (13.58 ± 0.42 to 7.43 ± 0.99 %) and more lighter green colour of CAL powder produced, L* (20.27 ± 0.12 - 23.77 ± 0.69). Besides that, the increased in both inlet air temperature and maltodextrin concentration reduced the RSA of the spray dried powder. From the study, it can be concluded that the production of spray dried CAL powder is feasible and the addition of maltodextrin as the drying agent has provided a greater impact to the physicochemical properties of the powder.
Maltodextrin
Centella
Water activity
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Pellet
Inert
Microcrystalline
Matrix (chemical analysis)
Pharmaceutical technology
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