Stability of polymer-complexed phospholipid vesicles
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Dipalmitoylphosphatidylcholine
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ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSpontaneous transfer of gangliotetraosylceramide between phospholipid vesiclesRhoderick E. Brown, Istvan P. Sugar, and Thomas E. ThompsonCite this: Biochemistry 1985, 24, 15, 4082–4091Publication Date (Print):July 1, 1985Publication History Published online1 May 2002Published inissue 1 July 1985https://pubs.acs.org/doi/10.1021/bi00336a042https://doi.org/10.1021/bi00336a042research-articleACS PublicationsRequest reuse permissionsArticle Views40Altmetric-Citations26LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Dipalmitoylphosphatidylcholine
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根据精力能量守恒定律和表面压力等温线， dipalmitoylphosphatidylcholine (DPPC ) 和在在空气 / 水接口的纯 phospholipid 单层的 dipalmitoylphosphatidylglycerol (DPPG ) 的符合构造精力变化在压缩期间被导出。以绝对自由状态的 phospholipids 的优化符合构造被 Gaussian 98 软件模仿。基于后面的假设：(1 ) 符合构造精力变化被一张特殊契约的旋转主要引起；(2 ) 水表面附近的甘油的原子是活跃的；(3 ) 旋转被氢契约行动激发；(4 ) 契约的旋转是惯性的， conformational 变化的一条简化轨道被建议，以不同状态的 DPPC 和 DPPG 的符合构造被符合构造精力变化对二面的角度的阴谋决定。模仿的 phospholipid 单层的厚度与出版试验性的结果一致。根据以不同状态的分子的区域，在压缩过程的分子的取向也被开发。
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Molecular dynamics simulations have been used to study the spontaneous aggregation of a concentrated solution of dipalmitoylphosphatidylcholine (DPPC) molecules in water into a small vesicle. The molecules were represented in atomistic detail. Starting from a DPPC solution in water, an oblong vesicle with a long axis of 15 nm and short axes of 10 nm was formed spontaneously. After 90 ns of simulation, the vesicle contained a number of water pores. Water pores were shown to facilitate exchange of lipids between inner and outer leaflets. Lipid tails were shown to be less ordered in the inner leaflet of the vesicle, as compared to those in the outer leaflet of the vesicle and an equilibrated lamellar bilayer.
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Stabilization of small unilamellar liposomes: polymerization of surfactants in phospholipid vesicles
Cosonication of a styrene-containing surfactant H2CCHC6H4NHCO[CH2]10N+(C16H33)Me2Br–(1) with dipalmitoylphosphatidylcholine (DPPC) leads to mixed DPPC–(1) 300 Å diameter unilamellar vesicles which subsequent to photopolymerization maintain their morphologies for months; conversely, nonpolymerized vesicles undergo spontaneous growth to 700 Å diameter vesicles.
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Here, we use coarse grained molecular dynamics (MD) simulations to study the spontaneous aggregation of dipalmitoylphosphatidylcholine (DPPC) lipids into small unilamellar vesicles. We show that the aggregation process occurs on a nanosecond time scale, with bicelles and cuplike vesicles formed at intermediate stages. Formation of hemifused vesicles is also observed at higher lipid concentration. With either 25% dipalmitoylphosphatidylethanolamine (DPPE) or lysoPC mixed into the system, the final stages of the aggregation process occur significantly faster. The structure of the spontaneously formed vesicles is analyzed in detail. Microsecond simulations of isolated vesicles reveal significant differences in the packing of the lipids between the inner and outer monolayers, and between PC, PE, and lysoPC. Due to the small size of the vesicles they remain almost perfectly spherical, undergoing very limited shape fluctuations or bilayer undulations. The lipid lateral diffusion rate is found to be faster in the outer than in the inner monolayer. The water permeability coefficient of the pure DPPC vesicles is of the order of 10(-)(3) cm s(-)(1), in agreement with experimental measurements.
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Influence of a Neoglycolipid and Its PEO−Lipid Moiety on the Organization of Phospholipid Monolayers
The surface properties of the neoglycolipid (GlcNAcE3G28) and of its PEO−lipid (E3G28) moiety mixed with phospholipids (dipalmitoylphosphatidylcholine, DPPC; distearoylphosphatidylcholine, DSPC; diarachidoylphosphatidylcholine, DAPC; and dibehenoylphosphatidylcholine, DBPC) were studied in Langmuir monolayers at various mixture compositions and surface pressures. The π−A isotherms of the pure compounds revealed that because of the presence of the sugar group in its molecule, GlcNAcE3G28 collapsed at a higher surface pressure and occupied a larger molecular area than the PEO−lipid moiety. It was also observed that the presence of the PEO−lipid (E3G28) in the mixtures triggered a strong alteration of both phospholipid π−A isotherm profiles and surface diffraction spectra, an indication that the disordering of the initially structured phospholipid monolayers took place. Unlike E3G28, GlcNAcE3G28 did not disorganize phospholipid monolayers but generated a partial segregation of the film-forming components. The calculated excess free energies of mixing (ΔGexc) for GlcNAcE3G28−phospholipid mixtures enabled us to predict the stability of such systems.
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