Gestrinone Compared With Mifepristone for Emergency Contraception
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Abstract:
In Brief OBJECTIVE: To compare the efficacy of gestrinone with that of mifepristone for emergency contraception. METHODS: A randomized double-blind trial was conducted in five family-planning clinics in China. We randomly assigned 998 healthy women with regular menstrual cycles and negative urine pregnancy tests who were requesting emergency contraception up to 72 hours after unprotected coitus to receive single-dose 10 mg gestrinone (n=499) or 10 mg mifepristone (n=499). We monitored them to 7 days after the expected first day of their next menstrual period. The study was powered to detect a 5% failure rate between the two regimens. RESULTS: The treatment groups did not differ significantly; posttreatment pregnancy rates were 2.4% in the gestrinone group compared with 1.8% in the mifepristone group (P=.51). The majority of women menstruated the first day of expected menses, and groups did not differ regarding side effects. CONCLUSION: The effectiveness of 10 mg gestrinone is not significantly different from 10 mg mifepristone as an emergency contraceptive method. CLINICAL TRIAL REGISTRATION: ISRCTN Register, isrctn.org, ISRCTN87842530. LEVEL OF EVIDENCE: I The effectiveness of 10 mg gestrinone is not significantly different from 10 mg mifepristone as an emergency contraceptive method.Keywords:
Emergency Contraception
Hormone antagonist
Levonorgestrel
Aim: To investigate the efficacy, safety and possible complications after mifepristone administration to women as emergency contraception method.
Emergency Contraception
Hormone antagonist
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To study the efficacy of mifepristone or with anordrin for emergency contraception.300 healthy women were recruited within 7.2 hours after unprotected intercourse or contraceptive failure and randomly allocated into 3 groups. Group 1 (n = 100), mifepristone 25 mg twice with 12 hours apart; group 2 (n = 99), single dose of mifepristone 25 mg; and group 3 (n = 101), mifepristone 25 mg and anordrine 7.5 mg given once.No pregnancy occurred in group 1, while 1 pregnancy in each group 2 and 3. The contraceptive effectiveness were 100.0%, 83.8% and 86.1% for the 3 groups respectively. The overall menstruation disturbances and side effects were low.Both mifepristone 50 or 25 mg were effective for emergency contraception and no synergetic effects of anordrin in combination with mifepristone was shown in this study.
Emergency Contraception
Hormone antagonist
Menstruation
Abortifacient
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OBJECTIVE: To provide reference for safe use and evaluation of levonorgestrel emergency contraception in China. METHODS: By the means of literature retrieval and analysis, the reports of adverse drug reactions induced by levonorgestrel emergency contraception from MedWatch (FDA Medical Products Reporting Program), National Center for ADR Monitoring, WHO and State Contraceptives Adverse Reaction Surveillance Center were analyzed to find out the differences of types and data of adverse drug reactions induced levonorgestrel emergency contraception and analyze the reasons. RESULTS: There were large type and data differences of adverse drug reactions induced by levonorgestrel emergency contraception at home and aboard. CONCLUSION: The public education, professional training of issue personnel and the cognition of doctors and immediate processing are key to reduce and prevent the adverse drug reaction induced by emergency contraception.
Levonorgestrel
Emergency Contraception
Drug reaction
Adverse drug reaction
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This is an increased window of
treatment opportunity compared to
levonorgestrel, the only other dedicated
oral emergency contraceptive, which
is registered for use within three days
(72 hours) of intercourse. Despite more
than a decade of non-prescription
availability of levonorgestrel,
emergency contraception is currently
underutilised in Australia and
elsewhere in the world
Levonorgestrel
Emergency Contraception
Ulipristal acetate
Window of opportunity
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Levonorgestrel
Emergency Contraception
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For various reasons, each community may vary in their measures taking for emergency contraception, which has been a frequent necessity especially in the out-patient department of gynecology. In this article, the authors report the effect of single oral administration of low-dose mifepristone (25 mg) in emergency contraception, with a total effective rate of 80.89%.
Emergency Contraception
Oral contraception
Hormone antagonist
Induced Abortions
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Objective: To compare the effects of mifepristone and levonorgestrel on emergency contraception.Methods: 206 patients with no protective sex required emergency contraception within 72 h were randomly divided into group1(n=136) and group 2(n=70).In group 1,single oral mifepristone 25 mg;in group 2,oral levonorgestrel 0.75 mg and once more 0.75 mg after 12 h.Results: There were two cases of pregnancy in group 1 and three cases of pregnancy in group 2,the rate of failure was 1.47% in group 1 and 4.29% in group 2,the rate of effective contraception was 84.10% in group 1 and 61.34% in group 2,the rate of side reaction was 7.53% in group 1 and 17.14% in group 2.Conclusion: Both mifepristone and levonorgestrel are effective emergency contraceptives,but mifepristone for emergency contraception is better than levonorgestrel.
Levonorgestrel
Emergency Contraception
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Levonorgestrel
Emergency Contraception
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OBJECTIVE:To provide reference for the standardization of the instruction of levonorgestrel emergency contraception. METHODS:Instruction of levonorgestrel emergency contraception in the market was compared with the national regulations and foreign instruction of the same kind of productions in order to discover the problems in domestic specification. RESULTS:The major problems of domestic instruction of levonorgestrel emergency contraception included instructions without population limits, unclear frequency and interval of drug use,without attention to ADR of levonorgestrel emergency contraception,lack of pharmacy research data. CONCLUSIONS:The problems existing in domestic instruction of levonorgestrel emergency contraception are shortage of items and warnings of drug safety. Related administration departments and enterprises are suggested to modify and perfect the instruction of levonorgestrel emergency contraception.
Levonorgestrel
Emergency Contraception
Ulipristal acetate
Economic shortage
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Levonorgestrel
Emergency Contraception
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