pS10147-2, a3.7 kb multicopy plasmid isolated from Streptomyces coelicolor
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Abstract:
The multicopy plasmid, pS10147-2 (3.7 kb) was isolated from Streptomyces coelicolor IMET 40271. A restriction enzyme map of pS10147-2 was constructed. The pS10147-2 is probably a spontaneous deletion derivative of pIJ101.Keywords:
Streptomycetaceae
Restriction map
We report here that Streptomyces coelicolor A3(2) produces at least seven butyrolactone autoregulators: two of the IM-2 type, four virginiae butanolide type, and one A-factor type. The most abundant one corresponds to virginiae butanolide-C9 having a C2 side chain of nine carbons. Model butyrolactone compounds as well as extracts of S. coelicolor mycelia showed clear induction of morphological differentiation, implying that S. coelicolor A3(2) probably possessed butyrolactone-type autoregulator(s) controlling the morphological differentiation.
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Intergeneric crossing of the actinomycetes Streptoverticillium mycoheptinicum and Streptomyces coelicolor yielded recombinants which were mostly nonviable and unstable despite a relatively high frequency (10(-2)-10(-4)) at which their colonies appeared. The rare viable and stable recombinants were prototrophs. The structure of antibiotics in the hybrid cell may be modified as follows from the differences in the antibiotic activity of the LIA-973 hybrid and the parent strains.
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We report here that Streptomyces coelicolor A3(2) produces at least seven butyrolactone autoregulators: two of the IM-2 type, four virginiae butanolide type, and one A-factor type. The most abundant one corresponds to virginiae butanolide-C9 having a C2 side chain of nine carbons. Model butyrolactone compounds as well as extracts of S. coelicolor mycelia showed clear induction of morphological differentiation, implying that S. coelicolor A3(2) probably possessed butyrolactone-type autoregulator(s) controlling the morphological differentiation.
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Fifteen strains of Actinomycetales alleged to produce antibiotics belonging to the aureolic acid group, some of which are useful as antitumor agents, were compared taxonomically with Streptomyces cavourensis subsp. washingtonensis strain AUW-83, a strain which produces chromomycin antibiotics. Of these strains, Streptomyces aburaviensis ATCC 23869, Streptomyces minutiscleroticus ATCC 17757, and S. cavourensis subsp. washingtonensis strain AUW-83 are type strains. None of the strains were regarded as similar enough to strain AUW-83 to be placed in S. cavourensis subsp. washingtonensis. Bristol’s Streptomyces sp. C-14795, a chromomycin-producing strain which has not been previously reported in the literature, and S. aburaviensis ATCC 23869 appear to be different strains of the same species; the same is true of Streptomyces griseus no. 7 and Streptomyces sp. KCC S-1081 and of Streptomyces argillaceus F.D. no. 6590 and Streptomyces sp. M-198. However, to establish the identities and taxonomic relationships of these 15 strains, further studies involving direct comparisons with type and/or neotype strains of closely related nomenspecies will be required.
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