Increased Vasopressin Secretion and Release in Mice Transgenic for the Rat Arginine Vasopressin Gene
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The rat arginine vasopressin (AVP) genomic sequence has been utilized to develop a line of transgenic mice homozygous and heterozygous for the transgene. Expression of the rat AVP gene was demonstrated by Southern blotting and resulted in increased amounts of AVP in hypothalamus and frontotemporal brain cortex. Secretion of AVP from the neurohypophysial system results in an increased concentration of the hormone in the plasma and in an increased excretion in the urine in amounts three to five times those of normal mice. Extraneural ectopic hormone production was found only in the pancreas. Despite chronic hypersecretion of AVP, 24-hour urine volume and osmolality did not show evidence of increased antidiuretic hormone action on the kidney, so that, under basal conditions, the water balance in the animals is unaffected.Keywords:
Urine osmolality
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ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of arginine-vasopressins, modified in positions 1 and 2, as antagonists of the vasopressor response to the parent hormoneBernard Lammek, Piotr Rekowski, Gotfryd Kupryszewski, Per Melin, and Ulf RagnarssonCite this: J. Med. Chem. 1988, 31, 3, 603–606Publication Date (Print):March 1, 1988Publication History Published online1 May 2002Published inissue 1 March 1988https://pubs.acs.org/doi/10.1021/jm00398a018https://doi.org/10.1021/jm00398a018research-articleACS PublicationsRequest reuse permissionsArticle Views53Altmetric-Citations22LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
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Plasma osmolality
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The synthesis of three new arginine vasopressin (AVP) analogues with changes at position 1 and 8 is reported. They are: 1-(1-mercapto-4-methylcyclohexaneacetic acid)-8-D-arginine-vasopressin, 1-(4-tert-butyl-1-mercaptocyclohexaneacetic acid)-8-D-arginine-vasopressin and 1-(1-mercapto-4-phenylcyclohexaneacetic acid)-8-D-arginine-vasopressin. They all proved to be potent and selective antagonists of the vasopressor response to AVP. They lacked antagonism in the antidiuretic assay (AD), but retained small agonism in this system. The Arg8 substitution instead of Arg8 in case of the described AVP analogues did not lead to any significant change of antagonistic potency or selectivity.
Vasopressin Antagonists
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Plasma arginine vasopressin concentrations were measured in five healthy volunteers during postural change under conditions of dehydration and normal hydration. A rise in plasma arginine vasopressin was observed only after dehydration and standing for 40 min. Five further volunteers who developed presyncopal symptoms during orthostasis had exceedingly high plasma arginine vasopressin levels. Changes in plasma arginine vasopressin concentration occurred with no signficant alterations in plasma osmolality.
Plasma osmolality
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