P128 Intima media thickness of the common carotid artery is significantly higher in inflammatory bowel disease patients compared to healthy population
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Intima-media thickness
Carotid intima-media thickness (cIMT) is a surrogate marker of early atherosclerotic changes in children. cIMT-studies are hard to compare, due to variations in ultrasound protocols, especially regarding the common carotid artery (CCA) segment measured in relation to the bulb. This study's purpose was therefore to compare two distinct CCA segments in children, to see if cIMT values differ substantially according to the site of measurement. cIMT was assessed after power calculation in 30 children (15 girls) aged 8–17, using B-Mode ultrasound (5–13 MHz) at two CCA locations. The first measurement was performed over a distance of 1 cm immediately after the bulb (A), the second 1cm proximal the bulb (B) over the same distance of 1cm length. Means of end-diastolic far wall cIMT were compared between measurement A and B. cIMT in 30 participants was 0.51±0.06 mm for measurement A and 0.51±0.05 mm for measurement B. Results did not differ significantly (p = .947) over a distance of 2 cm after the bulb. According to our results, studies measuring CCA IMT within the first 2 cm, either close to the bulb or further proximal, can be compared. This will improve interpretation of data and application of reference values.
Intima-media thickness
Bulb
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Objective:To evaluate the relationship between common carotid artery (CCA) intima-media thickness (IMT), common carotid artery diameter (Dd) and carotid artery atherosclerosis (CAS) by ultrasonograph. Methods: The carotid arteries were assessed by PHILIPS IU22 color doppler ultrasonography in 40 patients with hypertension of high-risk group and 40 of mild dangerous group. IMT and Dd of common carotid arteries were measured in the two groups. Results: (1)The values of IMT and Dd were significantly higher in hypertensive patients of high-risk group than those of the mild dangerous group (P 0.05). (2)There were significant differences in isolated abnormal rates of IMT or Dd, and both IMT and Dd in hypertensive patients of high-risk group compared with those of mild dangerous group(P 0.05 or P 0.01). (3) After adjusting for age, gender, smoking and family history, the levels of blood pressure, blood glucose and blood fat still play an extremely positive role in the increasing of IMT and Dd. Conclusion: The enlargement of common carotid artery IMT and Dd was an objective marker to CAS, but coexistent abnormalities of IMT and Dd were more sensitive to CAS.
Intima-media thickness
Tunica intima
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Rotterdam Study
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Aim To determine whether small,dense low density lipoprotein cholesterol( sdLDLC) affects common carotid artery intima-media thickness( CCA-IMT) or not. Methods 130 patients who had dyslipidemia,diabetes mellitus,hypertension,or smokers participated in this experiment. SdLDLC was collected from automatic analyzer,and CCA-IMT analysis datas were obtained from high-resolution B-mode ultrasound. Results The sdLDLC in CCA-IMT thickening group was significantly higher than that in CCA-IMT normal group( 43. 97 ± 11. 35 mg / dL vs 26. 01 ± 7. 62 mg / dL,P 0. 001). The positive association of CCA-IMT with sdLDLC was significant( r = 0. 857,P 0001). Conclusions This result indicates that sdLDLC was the best marker of CCA-IMT and suggests that quantitative measurement of sdLDLC provides useful information for the risk assessment of CCA-IMT.
Intima-media thickness
Dyslipidemia
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The intima-media thickness (IMT) of the common carotid artery (CCA) is an established indicator of cardiovascular disease (CVD). There have been reports about the difference between the left and the right sides of the CCA IMT and its importance when evaluated with various risk factors as well as their association with the risk of stroke. In this study, we use an automated system based on snakes, for segmenting the CCA and perform measurements of the IMT of the carotid artery and provide their differences between the left and right sides. The study was performed on 205 longitudinal-section ultrasound images acquired from 87 men and 118 women at a mean±SD age of 63±10.47 years, out of which 51 had cardiovascular symptoms. A cardiovascular expert manually measured the IMT on the left CCA side (mean±standard deviation = 0.79±0.21 mm) and the right CCA side (0.76±0.33 mm). The left and right IMT automated measurements were 0.70±0.15 mm and 0.66±0.15 mm, respectively. We found no statistical significant differences: 1) between the left and right IMT measurements, for both the manual and automated measurements, and 2) between the manual and automated measurements for both sides. These findings suggest that the measurement of the CCA IMT on one side only is enough (and this is in agreement with other studies), as well as automated measurements can be used.
Intima-media thickness
Stroke
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Objectives To study the relationship between ambulatory pulse pressure(PP) and carotid artery intima-media thickness in elderly patients with essential hypertension. Methods The 24 hours ambulatory blood pressure monitoring was performed in a total of 103 elderly patients with essential hypertension. According to day-and night-time average PP,the patients were divided into two groups: PP60 mm Hg group and PP≥60 mm Hg group. The ultrasound technique was used to detect the carotid artery intima-media thickness. The comparison of difference of the carotid artery intima-media thickness and the correlative analysis of every parameter of the carotid artery intima-media thickness and PP in two groups was done. Results There was significantly different in the carotid artery intima-media thickness between PP60 mm Hg group and PP≥60mmHg group (P0.01). There was better correlation of PP and the carotid artery intima-media thickness,especially the correlation of nocturnal PP and the carotid artery intima-media thickness was the best. Conclusions The ambulatory PP (especially nocturnal PP) of the elderly patients with essential hypertension are the most important factors which influent the carotid artery intima-media thickness.
Intima-media thickness
Essential hypertension
Pulse pressure
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To determine site specific carotid intima-media thickness: common-carotid artery and carotid bifurcation in hypercholesterolemia patients as a marker for atherosclerosis.Fifty patients with hypercholesterolemia and twenty controls were selected after getting informed consent regarding the investigation of carotid- intima media thickness by B-mode ultrasound. All the patients of hypercholesterolemia with LDL-C > 160mg/dL had family history of coronary artery diseases. This procedure was carried out in the Radiology Department of Dr. Ziauddin Hospitals. Measurement of carotid -intima media thickness, B-mode ultrasonography of common carotid artery, carotid bifurcation and internal carotid artery (left and right carotid arteries) was performed with Toshiba (M# SSA-580A/E2) ultrasound scanner with linear probe. The posterior or far wall of the carotid artery is, the distance between the leading edge first bright line (lumen -intima interface) and the leading edge of the second bright line (media-adventitia interface) of far wall was recorded as intima -media thickness. The average mean of six segments of intima-media thickness was taken as mean CIMT of right and left common carotid, bifurcation and internal carotid arteries.Maximal CIMT was significantly increased at sites common carotid, carotid bifurcation and internal carotid arteries in fifty patients with hypercholesterolemia as compared to controls. At carotid bifurcation mean of maximal CIMT was (0.9+ 0.3mm). Range of maximum CIMT in hypercholesterolemia patients was (0.8- 3.3mm) and in controls (0.4- 0.8 mm). The thickness was more frequently increased at site of bifurcation.Carotid intima- media thickness in hypercholesterolemia patients was increased and carotid bifurcation was site that has shown greater increase in intima-media thickness and plaques in these patients predict high risk for atherosclerosis.
Intima-media thickness
Carotid bifurcation
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Intima-media thickness
Carotid artery disease
Value (mathematics)
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