Optically active monosubstituted cymantrene derivatives. Relationship of chiroptical characteristics with absolute configuration of the compounds
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Absolute Configuration
Cotton effect
Chirality
The absolute configuration of chiral sulfoxides is determined by means of host-guest complexation that leads to the induction of axial chirality in an achiral host. The central to axial induction of helicity is rationalized by a simple recognition of the relative length and size of the substituents attached to the S-center. This technique is used to determine the absolute configuration of chiral sulfoxides, requiring micrograms of sample, without the need for prefunctionalization.
Chirality
Asymmetric induction
Absolute Configuration
Axial Chirality
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The results of the “Chirality measurement” circular dichroism along different viewing directions within molecules and phases—the anisotropy of circular dichroism can give suitable information in order to check helicity rules or to analyze the suprastructural chirality of films of organic materials, respectively. These results of the ACD spectroscopy (the CD of anisotropic phases and oriented molecules) show that in an oriented state different information about “chirality” will be gained from different viewing directions. ACD measurements of α,β-unsaturated ketosteroids, TADDOLes and binaphthol derivatives were analyzed. The chiral induction of cholesteric phases, the helical twisting power, is introduced as another chirality measurement which may possibly be a new relative method for the determination of the absolute configuration. Chirality 12:278–286, 2000. © 2000 Wiley-Liss, Inc.
Chirality
Helicity
Cotton effect
Vibrational Circular Dichroism
Dichroism
Axial Chirality
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The absolute configuration of (+)-α-methylphenylglycine was proved to be S series by the chemical correlation with R (-)-isovaline. Chemical scheme employed was shown in Chart 1. Moreover, in the course of the chemical correlation, the absolute configuration of (+)-1-methyl-1-phenylpropylamine was also proved to be R series. Preliminary experiments using racemic compounds were also described.
Absolute Configuration
Cotton effect
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Absolute Configuration
Carbon fibers
Asymmetric carbon
Active carbon
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Optically active 3-substituted 2, 3-dihydro-1, 3, 4-thiadiazoles (2-5) were synthesized by the reaction of aldehyde methylthio(thiocarbonyl)hydrazones (1) and chiral 5-substituted 1, 3-dioxolane-2, 4-diones. The absolute configurations of compounds 2-5 were deduced from their circular dichroism spectra.
Absolute Configuration
Thiadiazoles
Dioxolane
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Absolute Configuration
Optical rotatory dispersion
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The absolute configuration of (+)-α-methylserine ((+)-IX) obtained from natural source, has been elucidated to be S-configuration by the chemical correlation with (+)-isovaline ((+)-VII), at the same time the absolute configuration of (+)-2-amino-2-methyl-3-butenoic acid ((+)-XI) has also been proved to be S-series. Chemical schemes employed were shown in Charts 1 and 2. Optically active hydantoins (V and VIII) used in the correlation were prepared by the direct resolution of racemic hydantoins with brucine. Preliminary examinations using racemic compounds were also reported.
Absolute Configuration
Brucine
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Circular dichroism (CD) is a physical property observed in chiral molecules by inducing the difference of absorption between left- and right-handed circularly polarized light (CPL). Circular dichroism spectroscopy is widely used in the field of chemistry and biology to distinguish the enantiomers, which typically show either positive or severe side effects in biological applications depending on the molecular structures’ chirality. To effectively detect the chirality of molecules, diverse designs of nanostructured platforms are proposed based on optical resonances that can enhance the optical chirality and amplify the signal of circular dichroism. However, the underlying physics between the optical chirality and the resonance in a nanostructure is largely unexplored, and thus designing rules for optimal chiral detection is still elusive. Here, we carry out an in-depth analysis of chiral enhancement (C enhancement) in nanostructured surfaces to find the relationship between optical resonances and chirality. Based on the relations, we optimize the nanostructured metasurface to induce effective chiral detection of enantiomers for diverse conditions of molecule distribution. We believe that the proposed designing rules and physics pave the important pathway to enhance the optical chirality for effective circular dichroism spectroscopy.
Chirality
Vibrational Circular Dichroism
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Chirality
Absolute Configuration
Planar chirality
Cotton effect
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Vibrational circular dichroism( VCD) was applied for study of the absolute configuration of chiral axial bis-carboline with N—O function. The computational results exhibite that(-)-biscarboline derivative should have a S absolute configuration. At the same time,electronic circular dichroism( ECD) and optical rotation( OR) methods were also used to study its absolute configuration. The results show that the three diffe-rent conclusion from VCD,ECD and OR methods should give a same conclusion,namely,this(-)-biscarboline derivative should have a S absolute configuration.
Absolute Configuration
Vibrational Circular Dichroism
Optical Rotation
Derivative (finance)
Chirality
Specific rotation
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