Cutaneous verrucous carcinoma - report of three cases with review of literature.
Mariana CostacheLaura Tatiana DesaL MitracheOana Maria PătraşcuAdrian DumitruDiana CostacheEmanuel AlbuMaria SajinOlga Simionescu
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Abstract:
Verrucous carcinoma is a rare variant of squamous cell carcinoma. It is well differentiated and rarely metastases but can sometimes be very aggressive locally in depth. The paper presents three cases of cutaneous verrucous carcinoma with different localizations. The first patient shows a lesion in the sacrogluteal region, the second one presented a tumor localized on the auricle (external ear), and the third patient showed a tumor on the sole of the foot. All patients underwent tumor excision and the histopathological diagnosis was verrucous carcinoma. In the first two cases, the surgery was completely curative by excision of the tumors. In the last case, the patient had relapsed and due to the aggressive nature of the tumor, which infiltrated the deeper plans, the tumor had reached the bone. None of the patients showed any metastases.Keywords:
Verrucous carcinoma
Auricle
Surgical excision
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Verrucous carcinoma
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Verrucous Carcinoma Variant of Squamous Cell Carcinoma: Review of Literature Verrucous Carcinoma is a infrequent variant of well differentiated squamous cell carcinoma and has some distinctive characteristics clinically and histologically diverse from a archetypal oral squamous cell carcinoma. Verrucous carcinoma grows gradually, has a tendency of local invasion, and seldom metastasizes. In the present article we discuss about etiology, pathogenesis and the management of this uncommon tumor with a detailed review of literature.
Verrucous carcinoma
Etiology
Pathogenesis
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Keratoacanthoma
Verrucous carcinoma
Foot (prosody)
Skin grafting
Surgical excision
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Verrucous carcinoma is an unusual, non-metastasizing, distinct variant of squamous cell carcinoma composed of four subtypes according to the site of occurrence: oral type, anogenital type, plantar type, and other cutaneous sites.Oral type verrucous carcinoma usually shows slow progression with a low incidence of metastases.Treatment of verrcous carcinoma is challenging; multiple medical and surgical therapies are often attempted, with limited success.We reported on 2 cases of verrucous carcinoma of the lip treated with topical imiquimod and debulking therapy.(Ann Dermatol 23(S1) S68∼S71, 2011)
Verrucous carcinoma
Imiquimod
Debulking
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Verrucous carcinoma is a highly differentiated variant of squamous cell carcinoma with a high local recurrence rate. Few studies of primary verrucous carcinoma of the auricle have reported on the surgical outcome. The authors present herein a case in which a verrucous carcinoma of the auricle was successfully removed and reconstructed using a retroauricular pull-through island flap, and the authors briefly review the relevant literature.
Verrucous carcinoma
Auricle
Surgical excision
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Case 1 was first seen for a neck tumor (squamous cell carcinoma), but the primary site later proved to be the auricle. Total removal of the auricle with radical neck dissection was performed. In case 2, leukomelanoderma of the face was associated with a growth on the auricle first diagnosed as cutaneous horn. This recurred after repeated cryosurgical treatments for about a month. Biopsy revealed squamous cell carcinoma. Partial auricular resection was performed. There have been no signs of recurrence in either cases.
Auricle
Neck dissection
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Verrucous carcinoma (VC) is a variant of squamous cell carcinoma. It most commonly affects the oral cavity with buccal mucosa being the most common site affected. Clinically it has proliferative finger-like projections or a cauliflower-like appearance which is a significant factor in its diagnosis. It is more common in tobacco user males. The histopathological diagnosis of VC is difficult and requires immense experience to report a case of VC. Though VC is described as a benign lesion with minimum aggressive potential but long-standing cases have shown transformation into squamous cell carcinoma. Therefore, early diagnosis and surgical excision of the lesion are the most appropriate treatment modality of VC.
Verrucous carcinoma
Oral submucous fibrosis
Buccal mucosa
Malignant Transformation
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Verrucous carcinoma, a variant of squamous cell carcinoma, was first described as a distinct clinical and histopathological entity by Ackerman in 1948. In this paper, two cases of verrucous carcinoma of the oral cavity are reported. One case was treated by surgical excision, but the other rejected the treatment. The first case is free from recurrence as of today, 4 years and 4 months after surgery.Ultrastructural observations demonstrated that gap junctions and desmosomes were numerously found in the verrucous carcinoma.A well preserved intercellular junction might be rclatcd to a better prognosis of this lesion in comparison with invasive carcinomas.
Verrucous carcinoma
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Oral verrucous carcinoma (OVC) is a variant of oral squamous cell carcinoma which shows a local invasive pattern without any distant metastases. Accurate diagnosis of OVC depends on a careful association between clinical and histological features of the lesion. This paper reports a case of OVC over mandibular alveolar mucosa, mimicking Candidiasis. Use of diode laser for the management of the lesion is also described.
Verrucous carcinoma
Oral mucosa
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