Outbreak of contact sensitization to methylisothiazolinone: an analysis of F rench data from the REVIDAL‐GERDA network
S. HosteingNicolás MeyerJ. WatonA. BarbaudJ.‐L. BourrainNadia Raison‐PeyronBrigitte FelixBrigitte Milpied‐HomsiM.C. Ferrier Le BouëdecMichel CastelainD Vital-DurandM. DebonsEvelyne ColletM. Avenel-AudranP. Mathelier‐FusadeChristophe VermeulenH. AssierGwendoline GenerIsabelle Lartigau‐SezaryAmandine Catelain‐LamyF. Giordano‐Labadie
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Summary Background The preservative methylisothiazolinone ( MI ) is used in combination with methylchloroisothiazolinone ( MCI ), but the MCI/MI mixture has been identified as highly allergenic. MI is considered to be less allergenic, and since the mid‐2000s has been widely used alone, but is now clearly identified as a contact allergen. The F rench V igilance N etwork for D ermatology and A llergy of the S tudy and R esearch G roup on C ontact D ermatitis ( REVIDAL‐GERDA ) added MI to its baseline patch testing series in 2010. Objective To evaluate the change in the proportion of MI ‐positive tests in F rance between 2010 and 2012. Patients/materials/methods We conducted a nationwide, multicentre, retrospective study of all MI ‐tested patients between 2010 and 2012. Results Sixteen centres participated in the study (7874 patients were tested). Patch tests were performed mainly at a concentration of MI 200 ppm aq. We observed a significant increase in the proportion of MI ‐positive tests in 2012 and 2011 as compared with 2010 (5.6%, 3.3%, and 1.5%, respectively; p < 0.001). Conclusions We report a significant increase in the number of MI ‐positive tests. MI is confirmed to be a rapidly emerging allergen, as also observed in other E uropean countries.Cite
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Seperti pada dewasa, teknik regional anestesi pada pediatrik kini makin popular digunakan oleh ahli anestesikarena keuntungannya. Namun demikian selalu ada risiko dan kemungkinan timbulnya komplikasi dari setiap tindakan yang dilakukan, termasuk tindakan anestesi regional pada pediatrik. Insidensi komplikasi anestesi regional pada pediatrik tidak banyak, dan kalaupun terjadi komplikasi adalah minor. Komplikasi bisa diakibatkan dari identifikasi ruang saraf, alat, obat, teknis tindakan anestesi regionalnya dan komplikasi lainnya.Walaupun tidak banyak kejadian komplikasi regional anestesi yang dilaporkan pada pediatrik, dan bukanlah komplikasi yang fatal, teknik regional anestesi pada pediatrik harus dilakukan dengan lebih hatihati, pertimbangan risiko dan keuntungannya untuk menghindari terjadinya komplikasi, terlebih karena kebanyakan komplikasi dapat dihindari dengan mempelajari teknik yang benar, menggunakan peralatan yang sesuai, dan sangat menerapkan prinsip keamanan pada pasien dengan baik.
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Genentech is partnering with the German cancer company Affimed to develop immunotherapies for multiple kinds of solid and blood cancers. Affimed is developing therapies that engage natural killer cells of the innate immune system to help direct them to attack cancer cells. Genentech will pay Affimed $96 million up front and up to $5 billion more in potential payments.
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Irritant and allergic contact dermatitis are commonly seen in patients complaining about itching, burning and irritation in the vulvar area. Irritation often precedes allergic sensitization. Clinically, irritant and allergic contact dermatitis can be difficult to distinguish. Diagnosis is made by history, clinical investigation and patch testing. Recommended patch test series are the standard series, a medicament series, the patient's own topical medicaments, popular remedies and other suspected products. A skin biopsy may be useful to establish the diagnosis of contact dermatitis, but it is usually not helpful for the differential diagnosis between irritant and allergic dermatitis.
Irritant contact dermatitis
Itching
Patch test
Patch Testing
Skin irritation
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Summary Paraphenylenediamine (PPD) is a potent skin allergen found in permanent hair dye and temporary henna tattoo ink. Several cases of adverse skin reactions to PPD have been reported in the literature. Here we present a case involving a patient who acquired a temporary tattoo while vacationing in Mexico and subsequently developed contact dermatitis at the tattoo site. He provided a history of permanent hair dye use in the past with associated cutaneous reaction. Temporary tattoos have become increasingly popular with travelers and as a result so have reports of associated allergic contact dermatitis. Of concern is cross‐reaction of PPD to related compounds, severe reactions in younger populations and sequelae including increased sensitization, permanent scarring, and persistent postinflammatory hyperpigmentation.
Hair dyes
Contact Allergy
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Lacquer
Contact Allergy
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Abstract Background When a patient is identified by patch testing as being sensitive to a specific contact allergen, he or she is generally advised to read the product labels and avoid products that contain the specific allergen. Patients are often confronted with difficult chemical names, synonyms, and cross‐reactants for individual allergens. At the same time, dermatologists may spend a considerable amount of time trying to educate their patients about the avoidance of these allergens and explaining which products may contain them. Methods We applied a new educational approach to inform patients about products that are free of their allergens. Results We present a patient with multiple contact allergens in whom the Contact Allergen Replacement Database was used to educate about specific allergens. This approach has proved to be an invaluable tool for both physicians and their patients in contact allergy counseling.
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Irritant contact dermatitis
Erythema
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