Antitumor and Cytotoxic Compounds from Marine Organisms

The first total syntheses of (±)-norphoebine, dehydrophoebine, oxophoebine, dehydrocrebanine, oxocrebanine and uthongine have been achieved. The crucial step involved the formation of ring C by a microwave-assisted direct biaryl coupling to produce the aporphine skeleton in high yields. The synthetic alkaloids were evaluated for their cytotoxicity against three human cancer cell lines MCF7, KB and NCI-H187. The results showed that uthongine was the best candidate of the series and it exhibited cytotoxicity against a human breast cancer MCF7 line with an IC50 = 3.05 μM

Cancer cell lines

10.1080/10286020.2016.1177025

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Citations (8)

Seven new meroditerpenoids, from the marine spongeStrongylophora strongylata, that inhibited the maturation of starfish oocytes

Journal of Asian Natural Products Research (2005)

Hongwei Liu Michio Namikoshi Kyoko Akano Hisayoshi Kobayashi Hiroshi Nagai

Seven new meroditerpenoids, strongylophorines 13–19 (1–7), have been isolated together with the four known strongylophorines 2 (8), 3 (9), 4 (10), and 8 (11) by a screening method using oocytes of the starfish Asterina pectinifera from a marine sponge Strongylophora strongylata collected at Iriomote Island, Okinawa, Japan. The structures were assigned according to their spectral data. Ten strongylophorines inhibited the maturation of starfish oocytes in the range 1.1–37.6 μM (IC50), while strongylophorine 4 (10) was not active at 250 μM.

Sponge

10.1080/1028602032000169604

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Citations (22)

Starfish saponins. Part 39. Steroidal oligoglycoside sulfates and polyhydroxysteroids from the starfish Asterina pectinifera

Gazzetta chimica italiana (1990)

Maria Iorizzi Luigi Minale Raffaele Riccio

Source

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Citations (16)

ChemInform Abstract: Starfish Saponins. Part 40. Structures of Two New “Asterosaponins” from the Starfish Patiria miniata: Patirioside A and Patirioside B.

ChemInform (1990)