Protein Synthesis and Degradation Change Rapidly in Response to Food Intake in Muscle of Food-Deprived Mice ,
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Myofibril
Protein Degradation
Protein metabolism
Complete protein
Polysome
Protein turnover
Muscle protein
The effects of growth-suppressing and muscle-wasting treatments on muscle protein turnover and amino acid concentrations were determined in vivo. All treatments depressed protein synthesis and some treatments depressed protein breakdown. Only prolonged starvation increased protein breakdown. Muscle protein mass is regulated primarily through alterations in protein synthesis in all except emergency conditions. The increased concentrations of the branched-chain amino acids indicate that they are unlikely to be involved in this regulation.
Muscle protein
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It is well recognized that muscle makes a major contribution to amino acid and protein metabolism in the body but many of the details are still obscure. An understanding of the effects of injury and disease on muscle protein turnover and amino acid metabolism requires much more basic information on the mechanisms for the mobilization of amino acids from lean tissue and the relative contributions of different tissues. Several methodological approaches are reviewed. Our current knowledge of the effects of injury and disease on amino acid balance and protein turnover in muscle is als reviewed. It is suggested that the effects may be broadly categorized as those causing rapid increases in protein turnover with breakdown exceeding synthesis, and those in which synthesis is depressed below breakdown. The former response is more likely following severe trauma and during sepsis and the latter more common after moderate injury and during malnutrition. A knowledge of the mechanisms of loss of amino acid from muscle tissue is vital to the design of rational therapeutic intervention.
Protein turnover
Protein metabolism
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Catabolism
Proteolysis
Protein turnover
Protein metabolism
Muscle protein
Protein Degradation
Myofibril
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Protein metabolism
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Protein Degradation
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Catabolism
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Muscle protein
Nitrogen balance
Protein Degradation
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Complete protein
Protein metabolism
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