Antimalarial Effect of Iron Chelators
14
Citation
80
Reference
10
Related Paper
Citation Trend
Keywords:
Anti malarial
Malarial parasites
Objective: Microscopic detection of parasites has been the reference standard for malaria diagnosis for decades. However, difficulty in maintaining required technical skills and infrastructure has spurred the development of non-microscopic malaria rapid diagnostic devices based on the detection of malaria parasite antigen. We evaluated the QDx MALARIA PAN/Pf rapid immunochromatograpic card test by comparing it with the conventional standard blood smear method for the detection of malaria. Material & Methods: A total of 325 specimens of blood from cases of fever (falciparum malaria 88, vivax malaria 168, mixed infection of falciparum and vivax malaria 44, controls 25) were investigated by QDx Malaria Rapid test and blood smear method. Results: The QDx Malaria Rapid test showed 96.6% sensitivity, 100% specificity and 96.9 % accuracy. However, these parameters were lower when the parasitaemia was less than 500 parasites /μL. Conclusion: QDx Malaria Rapid test was found to have enormous advantages over smear examination due to its high degree of sensitivity, specificity, speed and ease of performance. Key Words: Malarial parasite; QDx MALARIA PAN / Pf rapid immunochromatograpic card test; blood smearDOI: 10.3126/ajms.v1i2.2965Asian Journal of Medical Sciences 1 (2010) 75-79
Diagnosis of malaria
Vivax malaria
Malarial parasites
Rapid diagnostic test
Blood smear
Blood film
Cite
Citations (31)
Malarial parasites
Cite
Citations (0)
Malarial parasites
Plasmodium (life cycle)
Cite
Citations (2)
Intrinsic fluorescence properties, docking and a hemozoin inhibition assay were employed to study the mechanism of action of two structurally related pyrido-[1,2-a ]benzimidazole derivatives.
Plasmodium (life cycle)
Malarial parasites
Cite
Citations (10)
Malarial parasites
Plasmodium (life cycle)
Cite
Citations (70)
Anti malarial
Malarial parasites
Cite
Citations (0)
Malarial parasites
Cite
Citations (8)
Malaria parasites were first recognised in human blood by Charles Louis Alphonse Laveran (1845-1922). Laveran had trained in Paris and Strasbourg, and had worked in the environment of F. C. Maillot, who had developed quinine therapy in North Africa; Leon Colin, who was interested in malaria epidemiology; and Achille Kelsch and P. J. Keiner, who specialised in the pathology of malaria.
Quinine
Malarial parasites
Cite
Citations (0)
ABSTRACT Ultrastructural investigations of P. falciparum cultivated in vitro in human erythrocytes revealed new features of the feeding mechanism of the parasite. Mature trophozoites and schizonts take up a portion of the host cytosol by endocytosis which is restricted to cytostomes and which involves the invagination of both parasitophorous and parasite membranes. The resulting endocytic vesicles, surrounded by two concentric membranes, migrate towards the central food vacuole membrane. The external membrane of the endocytic vesicles apposes that of the food vacuole, leading to the internalization of vesicles bounded by a single membrane into the vacuolar space where they are rapidly degraded. We conclude from this sequence of events that endocytic vesicles fuse with the food vacuole. Treatment of infected cells with therapeutic concentrations of chloroquine inhibited the last step of the feeding process, i.e. vacuolar degradation. This was manifested by the accumulation within the vacuolar space of intact vesicles bounded by single membranes. The implications of these findings for the antimalarial activity of chloroquine are discussed.
Malarial parasites
Plasmodium (life cycle)
Cite
Citations (127)
Malaria is one of the most important transfusion associated infections in many parts of the world, particularly the developing countries where it is endemic. This study estimates the risk of acquiring malaria from a single unit of blood in North of Pakistan. A prospective study was conducted to investigate transfusion transmitted malaria in three major blood banks of Peshawar, Pakistan. A total of 1558 (1534 males and 24 females) healthy volunteer blood donors were screened for the presence of malarial parasites in thick and thin smears using microscopy. Nine donors (0.577%) were found positive for malarial parasite, with trophozoites and gametocytic stages of Plasmodium falciparum (1) and Plasmodium vivax (8). Majority of the donors (82.09%) belonged to age group 15 - 30 years. Donors who suffered from malaria in recent years were 28 in number and 3 of them were found positive for malaria in the present study. The results of the present study indicated that transfusion transmitted malaria is a risk in malaria endemic regions like Pakistan. Further research on this aspect using more sophisticated and advanced diagnostic techniques like enzyme-linked immunosorbent assay (ELISA) and polymerase chain reaction (PCR) are required for proper assessment of actual situation and control of transfusion transmitted malaria in Pakistan.
Malarial parasites
Volunteer
Plasmodium (life cycle)
Cite
Citations (22)