Anti‐B lymphocyte immunotherapy is associated with improvement of periodontal status in subjects with rheumatoid arthritis
Juliette CoatJulien DemoersmanSébastien BeuzitDivi CornecValérie Devauchelle‐PensecAlain SarauxJacques‐Olivier Pers
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Abstract:
Rheumatoid arthritis (RA) and periodontitis present many similar features. The benefits of anti-B lymphocyte therapy (rituximab) on reducing tissue resorption in RA prompted us to assess its potential efficacy on the periodontal status of patients with RA treated with rituximab.Periodontal status was assessed in 21 subjects with RA, divided into two groups: Group I consisted in 11 subjects assessed before their first infusion of rituximab and again 6 months later. Five of them were also assessed for up to 4 years after their first rituximab infusion. The 10 subjects in group II had received more than two courses of two rituximab infusions at the time of periodontal assessment.Pocket depth and attachment loss were significantly decreased 6 months after treatment with rituximab in group I. The periodontal status of the five subjects from group I followed for up to 48 months after rituximab treatment was improved irrespective of the clinical parameter observed. Patients from group II had a better periodontal status than patients from group I before treatment with rituximab.Anti-B lymphocyte therapy could be beneficial to improve periodontitis suggesting a major role of B cells in this disease.Cite
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Seperti pada dewasa, teknik regional anestesi pada pediatrik kini makin popular digunakan oleh ahli anestesikarena keuntungannya. Namun demikian selalu ada risiko dan kemungkinan timbulnya komplikasi dari setiap tindakan yang dilakukan, termasuk tindakan anestesi regional pada pediatrik. Insidensi komplikasi anestesi regional pada pediatrik tidak banyak, dan kalaupun terjadi komplikasi adalah minor. Komplikasi bisa diakibatkan dari identifikasi ruang saraf, alat, obat, teknis tindakan anestesi regionalnya dan komplikasi lainnya.Walaupun tidak banyak kejadian komplikasi regional anestesi yang dilaporkan pada pediatrik, dan bukanlah komplikasi yang fatal, teknik regional anestesi pada pediatrik harus dilakukan dengan lebih hatihati, pertimbangan risiko dan keuntungannya untuk menghindari terjadinya komplikasi, terlebih karena kebanyakan komplikasi dapat dihindari dengan mempelajari teknik yang benar, menggunakan peralatan yang sesuai, dan sangat menerapkan prinsip keamanan pada pasien dengan baik.
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Genentech is partnering with the German cancer company Affimed to develop immunotherapies for multiple kinds of solid and blood cancers. Affimed is developing therapies that engage natural killer cells of the innate immune system to help direct them to attack cancer cells. Genentech will pay Affimed $96 million up front and up to $5 billion more in potential payments.
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Abstract Lymphocytes from patients with rheumatoid arthritis were studied in one‐way stimulation mixed leukocyte culture (MLC) and results compared with cultured pairs of rheumatoid and normal lymphocytes. In 14 of 22 experiments, no lymphocyte stimulation was noted when rheumatoid arthritis lymphocytes obtained from unrelated patients were studied in MLC. Normal lymphocytes produced stimulation of rheumatoid cells in 16 of 22 instances, and rheumatoid lymphocytes induced transformation of normal subjects' lymphocytes in 19 of 22 experiments. Marked alteration in mutual lymphocyte stimulation was thus recorded when cells from some patients with rheumatoid arthritis were studied together.
Mixed lymphocyte reaction
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