High-energy collisions of protonated enantiopure amino acids with a chiral target gas
Kostiantyn KulykOleksii RebrovMark H. StockettJohn AlexanderHenning ZettergrenH. T. SchmidtRichard ThomasH. CederquistMats Larsson
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Fragmentation
Enantiopure drug
Collision-induced dissociation
Fragmentation
Collision-induced dissociation
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The low energy collision-induced dissociation, linked scan techniques and isotopic labeling experiment were used to investigate the unimolecular fragmentation of protonated N-hydroxyphthalimide under electron impact and chemical ionization conditions. It was found that this compound shows an unusual reactivity towards protonation. Two possible sites of protonation have been proposed to explain the corresponding fragmentation processes, one is that the protonation takes place on the oxygen atom of hydroxyl group, resulting in the loss of water and the other is the formation of an intermediary proton-bound complex in the fragmentation process, giving rise to the fragment ions of m/z 133 and m/z 135. The results show both cases are coexistence in the fragmentations of protonated N-hydroxyphthalimide, and the unimolecular fragmentation pathways are available.
Fragmentation
Collision-induced dissociation
Proton affinity
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Abstract Mass spectral fragmentation processes and pathways of a series of nitro, dinitro and trinitro derivatives of naphthalene have been studied. Collision‐induced dissociation mass spectra were obtained using a tandem BB mass spectrometer. Major fragmentation pathways included loss of NO 2 from the molecular ion, followed by loss of NO and/or CO. Additional fragmentations included loss of OH from the molecular ion ion some of the compounds investigated.
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Collision-induced dissociation
Tandem
Polyatomic ion
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Abstract A collision‐induced dissociation (CID) study of five synthesized nitramines was carried out using a hybrid EBQQ mass spectrometer. CID spectra were obtained in two modes: B/E linked‐scan mode and MS/MS mode using the EB sector combination as the first mass spectrometer and the QQ as collision cell and second mass spectrometer, respectively. Fragmentation pathways of the compounds were determined in the electron‐impact mode. It was found that dominant fragmentation pathways included the loss of OH, NO 2 and HNO 2 in addition to the loss of CH 2 NNO and CH 2 NNO 2 .
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Collision-induced dissociation
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Fragmentation
Collision-induced dissociation
Polyatomic ion
Tandem
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Characteristics of mass spectra of isomeric tetradecadien-1-ols were investigated by electron impact mass spectrometry, and mass spectral fragmentation pathways were proposed based on collision-induced dissociation experiments and mass-analyzed ion kinetic energy spectrometry. Copyright © 1999 John Wiley & Sons, Ltd.
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Collision-induced dissociation
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Abstract A collision induced dissociation study of a series of 2,4,6‐trinitroaromatic compounds was carried out using a tandem BB mass spectrometer. Fragmentation pathways of the compounds were determined in the electron impact mode. It was found that dominant fragmentation pathways include loss of OH˙ due to an ortho effect and loss of NO˙ due to the formation of resonance‐stabilized products.
Fragmentation
Collision-induced dissociation
Tandem
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Fragmentation
Uracil
Collision-induced dissociation
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Fragmentation
Collision-induced dissociation
Structural isomer
Polyatomic ion
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Abstract In order to establish the mechanism of CO loss occurring during metastable decomposition of protonated 1‐indanone, fragmentations of monocyclic [C 9 H 9 O] + isomers have been studied. These ions of known structure were prepared by CI protonation and fragmentation of the corresponding acids chlorides. It is demonstrated that the wide component of the [MHCO] + metastable peak induced by protonated 1‐indanone fragmentation is the result of fragmentation of the [C 6 H 5 CH 2 CH 2 CO] + isomer ion.
Fragmentation
Metastability
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