Correlation analysis between body composition and bone mineral density in postmenopausal women with type 2 diabetes mellitus
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Objective:To study the relationship between body composition and bone mineral density(BMD) in postmenopausal women with type 2 diabetes mellitus(DM).Methods:62 postmenopausal women without DM(NDM group) and 48 postmenopausal women with DM(DM group) were scanned by dual-energy X-ray absorptiometry(DEXA) for examination of L1～L4 normotopia,left hip,whole body BMD and body composition.The results were analyzed and compared between the two groups finally.Results:(1) The BMD of left femurs,lumbar spine(L1～L4) and whole body as well as body composite of whole body,trunk and left leg had no significant differences between the two groups.(2) In DM group,fat tissue mass(FTM) of whole body,lean tissues mass(LTM) of whole body and FTM of trunk were positively correlated with BMD of the lumbar spine and BMD of whole body,respectively.LTM of whole body,FTM and LTM of trunk were significantly positive correlated with BMD of left femur and whole body,respectively.(3) In NDM group,FTM of whole body,LTM of whole body and FTM of trunk were positively correlated with BMD of whole body,lumbar spine and whole femur except Ward's triangular area(P0.01～0.05) respectively,but LTM of trunk was only positively correlated with BMD of troch.Conclusion:Body composition and BMD in postmenopausal women with DM are of certain correlations that are different from those without DM.These differences may be related to metabolic disorders induced by DM.Keywords:
Whole body vibration
Dual-Energy X-ray Absorptiometry
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Objective To study the relationship between body composition and bone mineral density(BMD)in pre-and postmenopausal women.Methods 22 pre-and 62 postmenopausal women were sacnned with dual-energy X-ray absorptiometry(DEXA,GE LUNAR PRODIGY)for L1～4 of the lumbar spine,left femur,and total body BMD and body composition.Results The BMD of L1～4 of the lumbar spine,left femurs,and body,and lean tissues mass of whole body and trunk were significantly higher in premenopausal women group,compared with postmenopausal women.Group.Lean tissues mass(LTM)of whole body、trunk and left leg were significantly correlated with body BMD in premenopausal women;However body composition were not significantly correlated with of BMD L1～4 of the lumbar spine,left femur(including neck,troch,wards),respectively.LTM and fat tissues mass(FTM) of body and trunk were significantly correlated with BMD of total body,L3 and L4 of the lumbar spine,and left femur troch respectively.LTM and FIM of total body and FTM of trunk were significantly correlated with BMD of L1 and L2 of the lumbar spine,and left femur neck,respectly.LTM of trunk were significantly correlated with left femur troch BMD.Body composition of left leg were not significantly correlated with of BMD of lumbar spine,left femur,and total body.Conclusion LTM is a significant determinant of total body BMD in premenopausal women;LTM and FTM of total body and trunk were significantly correlated with BMD of the lumbar spine,left femur,and total body,further,FTM seemed to be predominant.
Dual-Energy X-ray Absorptiometry
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Aim – to study the relationship between body composition and bone mineral density (BMD) in postmenopausal women with rheumatoid arthritis (RA). Material and methods . 68 postmenopausal women, median age 59 [54; 63] years, with RA were included in the study. Bone mineral density (BMD) and body composition were assessed with dual energy X-ray absorptiometry. Results . 33 (48.5%) women had osteopenia, and 17 (25.0%) – osteoporosis (OP). Low lean muscle mass was found in 10 (14.7%) patients. There were positive correlations between different areal BMD and body weight, trunk fat, trunk lean muscle mass and total lean muscle mass. In the multivariate linear regression analysis total lean muscle mass was associated with BMD of lumbar spine (β=0.638; p=0.001) and total hip (β=0.473; p=0.008), and appendicular lean muscle mass, estimated using the appendicular muscle index, with femoral neck BMD (β=0.360; p=0.014). Conclusion . 73.5% of patients with RA had a reduced BMD, and 14.7% women – low muscle mass. The revealed significant association between the lean muscle mass and BMD of lumbar spine and proximal femur indicates the importance of detecting and correcting low lean muscle mass, as well as preventing its decline in order to prevent loss of BMD and osteoporotic fractures.
Osteopenia
Dual-Energy X-ray Absorptiometry
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Objective To investigate the effect of body composition on bone mineral density (BMD) in postmenopausal women with different glucose tolerances.Methods A total of 152 postmenopausal women aged 45～81 years were divided into two groups according to the results of oral glucose tolerance test,including 41 with T2DM and 111 with normal glucose tolerance(NGT).BMDs of anteroposterior lumbar vertebrae(AP),femeral neck(FN),total hip(T-hip)and the total bone mineral density(TBMD) were measured by a dual energy x-ray absorptiometry (DEXA) scan.Body composition was also measured by DEXA,and the fat tissue mass(FTM),lean tissue mass(LTM),percentage of truncal fat(Tru-fat%) and the total fat(Fat%) were calculated.Results LTM was positively correlated with BMDs at all measured sites in the NGT group,and it was also an independent predictor for BMDs at all sites (Beta=0.199～0.455,R2C=0.027～0.200,P0.01 or 0.05).The percentage of fat showed an inverse relationship with total BMD in NGT,and FTM was also an independent predictor of total BMD(Beta=-0.237,P0.05).In T2DM group,LTM had a positive correlation only with BMD of FN and total hip;the percentage of fat also had a positive association with BMD of FN and total hip;FTM was the independent predictor of BMD of FN and hip(Beta=0.427～0.475,R2C=0.166～0.182,P0.01),but not LTM.Conclusion LTM has an decreased protective effect on BMD in postmenopausal women with T2DM,but FTM shows a protective effect on FN and hip of T2DM women.Maintaining a certain weight and strengthening their muscle strength during slimming can help to maintain the bone mass of postmenopausal women with T2DM.
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Objective:To observe the bone mineral density(BMD)changes in female postmenopausal T2DM patients and to study their relationship with insulin resistance and body components.Methods:Twenty-six cases of postmenopausal women with T2DM and 26cases of normal control were enrolled in this study.The BMD at L1-4of lumbar spine and body muscle and adipose tissue contents were measured by using a dual-energy X-ray absorptiometry.Cubital venous blood was taken at the same time for measuring fasting blood glucose and plasma insulin.Homeostasis model assessment-insulin resistance(HOMA-IR)index was adopted for assessing insulin resistance.Results:BMD values in L1as well as HOMA-IR index were higher in T2DM patients than those in controls.The lumbar spine BMD of L1,L2and L3in T2DM patients was positively correlated with HOME-IR(r=0.42,0.45,and 0.41,respectively,P0.05).BMD in L1positively correlated with the muscle contents(r=0.44,P0.05).Conclusion:The lumbar spine BMD in female postmenopausal T2DM patients was higher than that of normal controls.Insulin resistance and muscle content may be BMD protective factors.
Dual-Energy X-ray Absorptiometry
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Objective To determine the independent effect and relative contribution of lean mass and fat mass to BMD in perimenopausal women. Methods The sample consisted of 90 sedentary perimenopausal women (age: 47.3± 8.2).Total body BMD, regional BMD, and soft tissue body composition were measured by dual-energy X-ray absorptiometry(HOLOGIC(r) Discovery A). Other measures including age, height, weight, and body mass index (BMI). Results Findings revealed that 21% of these perimenopausal women had low bone mass (osteopenia) in the lumbar spine and/or the femoral neck. Overall body fat mass(20675.129±5080.44)g had no relationships with BMD of lumber spine(0.91±0.177) g/cm~2(P0.05,r=-0.17)and the femur(0.99±0.102) g/cm~2(P0.05,r=0.158), and lean mass (39790.80±6551.54)g had no relationships with BMD of lumber spine (0.91±0.177) g/cm~2(P0.05,r=0.078),but have positive relation with the BMD of femur(P0.05,r=0.216). Weight (63.01±9.39) kg and BMI had positive relationships with BMD of lumber spine and the femur(P0.05). Conclusions These findings suggest that BMI and body lean mass, not fat mass, are significant contributors to femoral BMD in women.
Osteopenia
Dual energy
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Objective To study the relationship between body composition and bone mineral density(BMD) in men with type 2 diabetes mellitus.Methods 125 men with diabetes mellitus(DM) were scanned with dual-energy X-ray absorptiometry(DEXA,GE LUNAR PRODIGY) for L1-L4 of the lumbar spine,left femur,and total body BMD and body composition.According to body mass index(BMI),all patients were divided into two groups,DM non-Obesity(DMNO)group(BMI25 kg/m2),and DM Obesity(DMO)group(BMI ≥25 kg/m2).Results The BMD of the lumbar spine(L1-L4) and left femurs(except Wards triangle) of DMNO were significantly higher than that of DMO.The fat tissue mass(FTM),percentage of FTM and lean tissues mass(LTM) of whole body,trunk,and left leg were of DMNO were significantly higher than that of DMO.In DMNO group,LTM of left leg was significantly positive correlated with BMD of femoral neck,femoral greater trochanter,femoral shaft,and whole left femur,and BMD of L1,L2 and L3,respectively(P0.01 or P0.05).LTM of whole body was significantly positive correlated with BMD of femoral neck,femoral shaft,and whole left femur,and BMD of L2,respectively(P0.01 or P0.05).LTM of trunk was significantly positive correlated with BMD of femoral greater trochanter and L2,respectively(P0.05).There were significantly positive correlation between LTM of whole body and L1,and between LTM of trunk and L1.In DMO group,LTM of left leg was significantly positive correlated with BMD of femoral neck,femoral shaft,and whole left femur,but was not correlated with BMD of lumbar spine.FTM of whole body was significantly positive correlated with BMD of L3 and L4,respectively(P0.05).FTM of trunk was significantly positive correlated with BMD of L1.Conclusion LTM of body is more significantly positive correlated with BMD of the left femur than that with BMD of the lumbar spine.FTM of body were only significantly positive correlated with BMD of the lumbar spine in men with type 2 DM.
Trochanter
Greater trochanter
Dual-Energy X-ray Absorptiometry
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Dual-Energy X-ray Absorptiometry
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Bone loss is known to be accelerated during menopause. The postmenopausal period with advancing age has also been associated with a decrease in lean body mass, an increase in body fat mass and increase in body weight. This study investigated the relative contribution of lean body mass and body fat mass to bone mineral density (BMD) in 139 healthy postmenopausal Chinese women in Kuala Lumpur. Total body, lumbar spine (L2-L4), femoral neck and total hip BMD were measured using dual-energy X-ray absorptiometry (DXA). Findings revealed that 80% of the Chinese postmenopausal women had low bone mass (osteopenia) and 8% were osteoporotic at the lumbar spine and/or femoral neck. Overall, body fat mass showed a positive correlation with BMD at all sites (total body, r = 0.265, p < 0.001; lumbar spine r = 0.214, p < 0.05, femoral neck r = 0.254, p < 0.001; total hip r = 0.332, p < 0.001). Similarly, lean body mass was positively correlated with BMD at most sites (Total body r = 0.239, p < 0.001; femoral neck r = 0.365, p < 0.001; total hip r = 0.352, p < 0.001) except at the lumbar spine. In a multiple stepwise regression analysis body fat mass was a significant predictor for BMD for total body (p < 0.0001) and lumbar spine (p < 0.005) BMD, while lean body mass was the major determinant of BMD at the femoral neck and total hip (p < 0.0001). These data suggested that both fat and lean mass were significant determinants of BMD, the former playing a greater role than lean mass in postmenopausal women. Therefore, postmenopausal women need to avoid being too underweight (and thus having too low body fat) and to maintain lean body mass to protect against osteoporosis.
Osteopenia
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Objective To evaluate the association of body composition with bone mineral density(BMD) in patients with type 2 diabetes mellitus,and to assess the role of fat and lean masses in maintaining the bone content. Methods 76 type 2 diabetics with mean age of 63\^8 years,mean duration of disease 6\^9 years,mean HbA 1c 9\^2% were involved in the study.BMD,lean mass,fat mass of total and regional part of the body were determined using dual energy X\|ray absorptiometry (DEXA).The patients were divided into two groups according to BMD of lumbar spine, 2\|4:group 1 with osteoporosis ( n= 19) and group 2 without osteoporosis( n =57). Results There were no significant differences in body mass index(BMI) and fat mass between two groups ( P 0\^05).There were significant reductions in BMD and lean mass in regional part of the body in group 1 compared with group 2.There were no correlations between BMD and fat mass in total or regional part of the body ( P 0\^05).There were significant positive correlations between BMD and lean mass in regional part of the body in diabetics( P 0\^01). Conclusion The lean mass has a more important effect on BMD than the fat mass in patients with type 2 diabetes mellitus.
Dual-Energy X-ray Absorptiometry
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Objective To study the relationship of bout body mass index(BMI) with left lower extremity muscle content,the fat content and the left calcaneus,bone mineral density(BMD) in the healthy postmenopausal women in Jinzhou city.Methods Body composition and the left calcaneus BMD in 421 healthy postmenopausal women were determined by body composition detector and BMD detector respectively.Results The left calcaneus BMD has negatively correlation with the age factor,the left lower limb muscle volume and BMI are positively related,but the left lower limb muscle volume with fat volumes has no correlation.Conclusion BMI is an important influenced factor to BMD in postmenopausal women,exercise and increasing muscle volume play a major role in the prevention of osteoporosis.
Bone mineral content
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