Complete resolution of a squamous cell carcinoma of the skin using intralesional 5-aminolevulinic acid photodynamic therapy intralesional PDT for SCC
18
Citation
3
Reference
10
Related Paper
Citation Trend
Abstract:
We present an 82-year-old female patient with a 2-year history of an infiltrative squamous cell carcinoma (SCC) on her right cheek. The patient was treated with one intralesional photodynamic therapy (PDT) session using 10% 5-aminolevulinic acid solution. We used red light by a non-coherent light source at a light dose of 100 J/cm2 and a fluency rate of 100 mW/cm2. Complete clinical and histological response was achieved 3 months after the treatment procedure. Cosmetic outcome was evaluated as fair. The patient remains disease free with the absence of any clinical sign of recurrence 16 months after PDT. Long-term follow-up is needed for assessment of recurrences. Optimization of the therapeutic protocol, as well as justification of our results in larger studies are needed in order to elicit safe conclusions.Keywords:
Complete response
With continuous development of the study on photosensitizers and photodynamic light,application of photodynamic therapy in the treatment of cancer has become increasingly mature.Basic and theoretical study of photodynamic therapy,as well as the continued listing of new products,also bring to patients of the Gospel.Now the writer summarized this year's basic research and clinical study of photodynamic,and set out the relevant views.
Listing (finance)
Cancer Therapy
Cite
Citations (0)
Nonmelanoma skin cancer has attracted little research interest compared with melanoma, although the former has a 10-fold greater incidence. The aggressiveness of melanoma has diverted attention from other forms of skin cancer for which reliable information is lacking. Until the size of the problem and the need for resources are determined, research will not be forthcoming or justified. Nonmelanoma skin cancer is arguably one of the most common cancers in humans today and its incidence is increasing rapidly. Its low mortality rate detracts attention from the high morbidity, both psychologic and physical, with which it is associated and from the drain on health resources that it generates.
Squamous cell cancer
Sun Exposure
Cite
Citations (8)
Photodynamic therapy (PDT) is a light based therapy used to ablate tumors. As practiced in oncology a photosensitizing agent is applied and then activated by a specific wavelength and energy of light. This light energy in the presence of oxygen will lead to the creation of the photodynamic reaction which is cyto and vasculo toxic. This paper will review the mechanisms of action of PDT and how they may be manipulated to improve clinical outcome in cancer patients.
Light energy
Cite
Citations (595)
Photodynamic therapy is a new and effective technique for cancer treatment,and 5-aminolevulinic acid photodynamic therapy is demonstrated to be more safe and effective than other photodynamic therapy.The treatment indication has been enlarged in recent years.This article reviewed the advances of 5-aminolevulinic acid photodynamic therapy in dermatology and venerology.
Cancer Therapy
Cite
Citations (0)
Clinical overview skin and subcutaneous endobronchus oesophagus gynaecologic miscellaneous treatments photoradiation therapy for choroidal malignant melanoma nursing aspects of photodynamic therapy the laser technician's role in photodynamic therapy photodynamic therapy photodynamic therapy - mechanisms and new clinical approaches urologic uses of photodynamic therapy photodynamic therapy for brain tumours photosensitized inactiviation of viral and protozoan infections agents.
Technician
Cite
Citations (8)
Cite
Citations (5)
Age-Related Macular Degeneration Other Etiologies of Choroidal Neovascularization Diagnostic Imaging for Photodynamic Therapy: Fluorescein Angiography and Optical Coherence Tomography Treatment of Subfoveal Choroidal Neovascularization Photosensitizing Agents Treatment of Age-Related Macular Degeneration with Photodynamic Therapy Treatment Protocol of Photodynamic Therapy Practical Applications of Photodynamic Therapy Complications of Photodynamic Therapy Alternative Applications for Photodynamic Therapy
Etiology
Cite
Citations (1)
Cite
Citations (0)
Photodynamic therapy (PDT) kills cancer cells by converting tumour oxygen into reactive singlet oxygen ((1)O2) using a photosensitizer. However, pre-existing hypoxia in tumours and oxygen consumption during PDT can result in an inadequate oxygen supply, which in turn hampers photodynamic efficacy. Here to overcome this problem, we create oxygen self-enriching photodynamic therapy (Oxy-PDT) by loading a photosensitizer into perfluorocarbon nanodroplets. Because of the higher oxygen capacity and longer (1)O2 lifetime of perfluorocarbon, the photodynamic effect of the loaded photosensitizer is significantly enhanced, as demonstrated by the accelerated generation of (1)O2 and elevated cytotoxicity. Following direct injection into tumours, in vivo studies reveal tumour growth inhibition in the Oxy-PDT-treated mice. In addition, a single-dose intravenous injection of Oxy-PDT into tumour-bearing mice significantly inhibits tumour growth, whereas traditional PDT has no effect. Oxy-PDT may enable the enhancement of existing clinical PDT and future PDT design.
Cite
Citations (855)