Vapor phase synthesis of mesoporous silica thin films with a 3D pore structure
Takanori MaruoKaori NagataNorikazu NishiyamaYasuyuki EgashiraKorekazu UeyamaChristopher P. MuzzilloMichael P. TateHugh W. Hillhouse
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Vapor phase
Mesoporous organosilica
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Abstract In the past decade, mesoporous silica nanoparticles (MSNs) have attracted more and more attention for their potential biomedical applications. With their tailored mesoporous structure and high surface area, MSNs as drug delivery systems (DDSs) show significant advantages over traditional drug nanocarriers. In this review, we overview the recent progress in the synthesis of MSNs for drug delivery applications. First, we provide an overview of synthesis strategies for fabricating ordered MSNs and hollow/rattle‐type MSNs. Then, the in vitro and in vivo biocompatibility and biotranslocation of MSNs are discussed in relation to their chemophysical properties including particle size, surface properties, shape, and structure. The review also highlights the significant achievements in drug delivery using mesoporous silica nanoparticles and their multifunctional counterparts as drug carriers. In particular, the biological barriers for nano‐based targeted cancer therapy and MSN‐based targeting strategies are discussed. We conclude with our personal perspectives on the directions in which future work in this field might be focused.
Nanocarriers
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The catalysts of strongly acidic mesopore include the strongly acidic components on the pore wall of mesoporous materials,the surface of the mesopores reformed by sulfonic acid groups,the heat treatment of microporous zeolites and the wall of mesoporous materials containing the zeolite structure of strong acidity.The strongly acidic mesoporous catalysts of various types possess different synthetic methods and characteristics.The synthesis of strongly acidic mesoporous catalysts is systemically introduced in this paper and the research prospects of strongly acidic mesoporous catalysts are forecasted.
Mesoporous organosilica
Sulfonic acid
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Mesoporous organosilica
Thermal Stability
Template method pattern
Hydrothermal Synthesis
Specific surface area
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Characterization
Mesoporous organosilica
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Nanocarriers
Amorphous silica
Nanomaterials
Surface Modification
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The recent progress, particularly in this decade, in catalytic applications of mesoporous ZSM-5 was reviewed. Mesoporous ZSM-5 materials aim to combine the shape-selectivity from micropores of ZSM-5 with enhanced mass transportation from the additional mesoporosity in catalytic reactions. The reactions discussed in this review are classified into two types: (1) the reactions mainly occurred on the external surface or in the pore mouths of the mesoporous ZSM-5 and (2) the reactions mainly occurred in micropores of ZSM-5. The external acid sites of mesoporous ZSM-5 enable the reactions involving bulky reactants that exceed the size of ZSM-5 micropores; and the presence of mesoporosity which improves the mass transport of reactants as well as products, reduces diffusion limitation and accelerates catalytic reaction. Although the advantages of mesoporous ZSM-5 compared with the conventional one are closely related to high external surface area and large mesopore volume, the acidity, including the type, strength and amount of acid sites and Al distribution, should be taken into account when the mesoporous ZSM-5 is utilized as catalyst in a real reaction. Finally, future challenges and opportunities for mesoporous ZSM-5 materials are presented. Keywords: Catalysis, mesoporous zeolite, ZSM-5.
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Abstract Recent advancements in morphology control and surface functionalization of mesoporous silica nanoparticles (MSNs) have enhanced the biocompatibility of these materials with high surface areas and pore volumes. Several recent reports have demonstrated that the MSNs can be efficiently internalized by animal and plant cells. The functionalization of MSNs with organic moieties or other nanostructures brings controlled release and molecular recognition capabilities to these mesoporous materials for drug/gene delivery and sensing applications, respectively. Herein, we review recent research progress on the design of functional MSN materials with various mechanisms of controlled release, along with the ability to achieve zero release in the absence of stimuli, and the introduction of new characteristics to enable the use of nonselective molecules as screens for the construction of highly selective sensor systems.
Surface Modification
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Solid acid
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