Chlamydia pneumoniae in the Pathogenesis of Alzheimer’s Disease
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Pathogenesis
The characteristic of the dynamic time is coincidence with its internal pathogenesis.The pathogenesis,however,has different levels.The basic pathogenesis is located at the highest level.The basic pathogenesis guides the specific pathogenesis,and the later is subordinated to the basic one.From the study of the basic pathogenesis we can conclude that therapy in group combinating with individual therapy is the essence of differentiated treatment
Pathogenesis
Pathogenesis-related protein
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Objective:To investigate the relationships between chronic infection of chlamydia pneumoniae and Coronary heart disease(CHD).Methods:The IgG and IgM antibodies against chlamydia pneumoniae in 32 cases of CHD and 32 cases of non-atherosclerosis confirmed by coronary angiography were detected by fluoroscopic immunoassay.Results:The CHD group had a significantly higher titer of antibodies against chlamydia pneumoniae than that of the non-atherosclerosis group(71.88% vs 25.00%,P0.01).Conclusions: There was a strong correlation between chronic infection of chlamydia pneumoniae and CHD.
Chlamydophila pneumoniae
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Chronic and acute infectious diseases have been implicated in modifying the risk of atherosclerosis independently or in collaboration with conventional risk factors. During the past two decades, the discussion on microbial agents and atherosclerosis has mainly been centred on Chlamydia pneumoniae. The strongest evidence linking Chlamydia pneumoniae and atherosclerotic disease comes from in vitro experimental studies. In this review, we summarize and critically evaluate the available data of human diagnostic and therapeutic studies on the association of Chlamydia pneumoniae with atherosclerosis. Taking into account the human in vivo data, there is currently insufficient proof linking Chlamydia pneumoniae to atherosclerosis. At present, there are no indications for antibiotic treatment targeted at Chlamydia pneumoniae in the management of atherosclerosis.
Chlamydophila pneumoniae
Infectious agent
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While chlamydia is a sexually transmitted infection that predominately affects females, this article concerns men and chlamydia. This article discusses the epidemiology, aetiology and signs and symptoms associated with a chlamydia infection. An outline of the consequences following infection will be presented along with the recommended treatment regimen. Chlamydia has the potential to become the interface between men's health and women's health. Most cases of chlamydia in women are a result of sexual contact with an infected man, and nearly all cases of chlamydia in the male, therefore, are the result of sexual contact with an infected woman. Addressing the sexual healthcare needs of men in relation to chlamydia has the potential to prevent the detrimental effects chlamydia may have on the female.
Etiology
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Objective:To analyze the pathogenesis and correlative factors of acute upper gastrointestinal hemorrhage.Methods:90 cases with acute upper gastrointestinal hemorrhage from Jan 2010 to Jun 2012 in our hospital were selected as the research objectives.The pathogenesis,predisposition and correlative factors were analyzed using the statistical method.Results:HG,DU,GU were the main pathogenesis of acute upper gastrointestinal hemorrhage.Different pathogeneses had different predispositions(P0.01).Pathogenesis distribution in Youth group,middle-aged group,and older age-group were different(P0.01).Pathogenesis distribute in male and female had no significant difference(P0.05).Conclusions:There are lots of Pathogeneses of acute upper gastrointestinal hemorrhage,and pathogenesis distribution in different age classes is different.
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It has been recently suggested that Chlamydia Pneumoniae infection is a common finding among children with acute respiratory diseases. Chlamydia cell culture is difficult and time-consuming to perform. Polymerase chain reaction (PCR) is a more rapid but also more expensive technique used to identify Chlamydia in pharyngeal swab, but it can be performed only in few specialized laboratories. We tested a rapid enzyme immuno-assay to detect Chlamydia in 20 children with respiratory infections (mean age 3.29 years; male:female ratio = 12:8) and in 21 healthy children (mean age 4.70 years male:female ratio = 15:6). Prevalence of Chlamydia isolation from pharyngeal swab was very high in both patients and healthy children without a significative difference in the two considered groups (45% vs 42%, p = 0.8). Specific Chlamydia IgG antibodies were undetectable in all patients and healthy children. Nine out of 20 patients affected by acute respiratory disease were Chlamydia-positive and 11 out 20 were Chlamydia-negative: these two groups didn't differ in regard to clinical and laboratory features, whereas duration of symptoms was significantly longer in Chlamydia-positive patients (9.3 vs 5.5 days, p = 0.014). Our study suggests a high prevalence of Chlamydia pharyngeal swab positivity in both healthy and sick children. Diagnosis of Chlamydia infection was not feasible on the basis of the considered clinical and laboratory findings.
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Objective: To review some studies about the association between Chlamydia pneumoniae and Coronary artery disease.Methods: To collect,sort and analyze the past study information.Results: Studies suggest that Chlamydia pneumoniae is associated with atherosclerosis,but treatment with a bactericidal antibiotic effective against Chlamydia pneumoniae is not associated with marked reductions of cardiovascular events.Conclusion: It is necessary to revise the significance of preventing cardiovascular events by resisting Chlamydia pneumoniae.
Chlamydophila pneumoniae
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[Atherosclerosis and inflammation--role of chlamydia pneumoniae infection what do we know to date?].
Association of inflammation with atherosclerosis has been known for many years. Some organisms: Chlamydia pneumoniae, Helicobacter pylori, Cytomegalovirus, Herpesvirus were considered as possible infectious factors responsible for coronary artery disease development. Several studies reported strong association between chronic Chlamydia pneumoniae infection and atherosclerosis. In this review we presented clinical evidence for and against the hypothetical association between coronary arterial disease and Chlamydia pneumoniae.
Chlamydophila pneumoniae
Cytomegalovirus
Infectious agent
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Hypertension has complicated pathogenesis.Because of the complexity,in this article the hypertension pathogenesis was divided into several different levels to discuss,which were basic pathogenesis,syndrome pathogenesis,symptom manifestation pathogenesis,disease pathogenesis and micro pathogenesis.The relationship between the above levels and the theoretic and clinical values of each level were analyzed.The significance of syndrome pathogenesis in the study on hypertension pathogenesis was emphasized.
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The intracellular Gram-negative bacterium Chlamydia pneumoniae has been associated with atherosclerosis. The presence of Chlamydia pneumoniae has been investigated in fragments of the arterial wall with a technique for DNA identification.Arterial fragments obtained from vascular surgical procedures in 58 patients were analyzed. From these patients, 39 were males and the mean age was 65+/-6 years. The polymerase chain reaction was used to identify the bacterial DNA with a pair of primers that codify the major outer membrane protein (MOMP) of Chlamydia pneumoniae. The amplified product was visualized by electrophoresis in the 2% agarose gel stained with ethidium bromide, and it was considered positive when migrating in the band of molecular weight of the positive controls.Seven (12%) out of the 58 patients showed positive results for Chlamydia pneumoniae.DNA from Chlamydia pneumoniae was identified in the arterial wall of a substantial number of patients with atherosclerosis. This association, which has already been described in other countries, corroborates the evidence favoring a role played by Chlamydia pneumoniae in atherogenesis.
Ethidium bromide
Chlamydophila pneumoniae
Agarose gel electrophoresis
Arterial wall
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