A Functional Genomics Approach to the Analysis of Biological Markers in Alzheimer Disease
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Functional Genomics
Summary Functional genomics is transforming the way biological research is done in the 21st century. Functional genomics brings together high‐throughput genetics with multiparallel analyses of gene transcripts, proteins, and metabolites to answer the ultimate question posed by all genome‐sequencing projects: what is the biological function of each and every gene? Functional genomics is driving a shift in the research paradigm away from vertical analysis of single genes, proteins, or metabolites, towards horizontal analysis of full suites of genes, proteins, and metabolites. By identifying and measuring many, if not all of the molecular players that participate in a given biological process, functional genomics offers the prospect of obtaining a truly holistic picture of life. This review describes the tools that are currently being used for functional genomics work and considers the impact that this new discipline is likely to have in the future.
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Rice functional genomics is a scientific approach that seeks to identify and define the function of rice genes, and uncover when and how genes work together to produce phenotypic traits. Rapid progress in rice genome sequencing has facilitated research in rice functional genomics in China. The Ministry of Science and Technology of China has funded two major rice functional genomics research programmes for building up the infrastructures of the functional genomics study such as developing rice functional genomics tools and resources. The programmes were also aimed at cloning and functional analyses of a number of genes controlling important agronomic traits from rice. National and international collaborations on rice functional genomics study are accelerating rice gene discovery and application.
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Genomics promises to enrich the investigations of biology and biochemistry. Current advancements in genomics have major implications for genetic improvement in animals, plants, and microorganisms, and for our understanding of cell growth, development, differentiation, and communication. Significant progress has been made in the understanding of plant genomics in recent years, and the area continues to progress rapidly. Functional genomics offers enormous potential to tree improvement and the understanding of gene expression in this area of science worldwide.In this review we focus on functional genomics of wood quality and properties in trees, mainly based on progresses made in genomics study of Pinus and Populus.The aims of this review are to summarize the current status of functional genomics including: (1) Gene discovery; (2) EST and genomic sequencing; (3) From EST to functional genomics; (4) Approaches to functional analysis; (5) Engineering lignin biosynthesis; (6) Modification of cell wall biogenesis; and (7) Molecular modelling.Functional genomics has been greatly invested worldwide and will be important in identifying candidate genes whose function is critical to all aspects of plant growth, development, differentiation, and defense. Forest biotechnology industry will significantly benefit from the advent of functional genomics of wood quality and properties.
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Genomics research has gone into the post-genomics era characterized by functional genomics. In this paper, the concepts of genome, genomics and study methods of functional genomics are introduced, the advancement of plant functional genomics research are summarized.
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At present the main direction of study in genomics has been transferred from structural genomics to functional genomics which focuses on elucidating the function of genes.The research metheds of functional genomics,mainly include Expressed Sequence Tag(EST),Serial Analysis of Gene Expression(SAGE),cDNA microarrays and DNA chips,Reverse genetics,Proteomics and Bioinformatics.Functional genomics of plants has made new progress in the study of Arabidopsis,rice and grain,etc.
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Study of genomics from structural genomics era have entered to functional genomics era. Functional genomics utilize informations from structural genomics to study function of gene systematically. The characteristic of functional genomics is high-flux、large scale empirical method and statistics and computer analysis ,so it's application is very extensive in studying of tumor related gene. This text overview functional genomics and its application in related gene of uterine cervix cancer importantly.
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The research of plant genome has been transferred from the structural genomics focusing on determining the complete sequences of the genome to the functional genomics focusing on elucidating the biological function of genes.That plant functional genomics study is to give an answer to how gene controls various biological phenomena,obtaining valuable information from the data of structure genomics and expounding the function of DNA sequence.In recent years,main methods of studying the plant functional genomics include expressed sequence tag,serial analysis of gene expression,DNA micro array,reverse genetics and so on.It is currently being widely focused on the gene expression by transcript profiling and take us rapidly forward in our understanding of plant biological traits.
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Abstract Genomics promises to enrich the investigations of biology and biochemistry. Current advancements in genomics have major implications for genetic improvement in animals, plants, and microorganisms, and for our understanding of cell growth, development, differentiation, and communication. Significant progress has been made in the understanding of plant genomics in recent years, and the area continues to progress rapidly. Functional genomics offers enormous potential to tree improvement and the understanding of gene expression in this area of science worldwide. In this review we focus on functional genomics of wood quality and properties in trees, mainly based on progresses made in genomics study of Pinus and Populus. The aims of this review are to summarize the current status of functional genomics including: (1) Gene discovery; (2) EST and genomic sequencing; (3) From EST to functional genomics; (4) Approaches to functional analysis; (5) Engineering lignin biosynthesis; (6) Modification of cell wall biogenesis; and (7) Molecular modelling. Functional genomics has been greatly invested worldwide and will be important in identifying candidate genes whose function is critical to all aspects of plant growth, development, differentiation, and defense. Forest biotechnology industry will significantly benefit from the advent of functional genomics of wood quality and properties.
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In the wake of the completion of model species' whole genome sequencing,genomics have been improved from the structural-genomics area to the functional-genomics area.Being a forward science,genomics shows a highest activities and influences.Based on the achievements of structural genomics,all subjects in functional genomics have different principles,key technologies with characteristics and superiorities,and thus have special spheres of application and developmental trends.Functional genomics is giving rise to the born of diverse aimed new-sciences because of its integration with many aspects of modern sciences.
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Comparative genomics and functional genomics are two basic branches of plant genomics [...]
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