After 6years of intraperitoneal insulin administration IGF-I concentrations in T1DM patients are at low-normal level
Peter R. van DijkS. J. J. LogtenbergSimona I. ChisalitaChristina A. HedmanKlaas H. GroenierRijk O. B. GansNanne KleefstraHans J. ArnqvistHenk J.G. Bilo
7
Citation
17
Reference
10
Related Paper
Citation Trend
Anabolic Agents
Cite
Citations (10)
Cite
Citations (18)
Hyperglycemia with or without blood glucose in diabetes range is an emerging finding not uncommonly encountered in patients with COVID-19. Increasingly, all evidence currently available hints that both new-onset hyperglycemia without diabetes and new-onset diabetes in COVID-19 is associated with a poorer outcome compared with normoglycemic individuals and people with pre-existing diabetes.
2019-20 coronavirus outbreak
Cite
Citations (171)
Dose
Bolus (digestion)
Insulin delivery
Cite
Citations (1)
Medical record
Impaired fasting glucose
Cite
Citations (60)
The ability of insulin and some of its derivatives to compete with 125 I-insulin for the binding site in the membrane fraction prepared from the mammary gland of lactating mice is reported. The binding affinity decreased in the following order: insulin desoctapeptide-insulin tert-butyloxycarbonyl 3 -insulin tert-butyloxycarbonyl 2 -desoctapeptide-insulin. Insulin hexamethyl ester and its desoctapeptide in concentrations 5.5 . 10 -11 - 2 . 10 -5 M did not inhibit the binding of 125 I-insulin. The comparison of the ability to decrease the blood glucose level showed that tert-butyloxycarbonyl 3 -insulin had 5% of the activity of insulin and that the other derivatives had less than 0.5% of that of insulin.
Cite
Citations (0)
Objective: The current study aims to determine the frequency of diabetes mellitus in patients with COVID-19 infection. Methodology: Our cross-sectional study was conducted on 120 patients who presented with COVID-19 to Dr. Ziauddin Hospital, North Nazimabad, Karachi, from December 2021 to May 2022. The frequency of diabetes in these patients was determined. Results: In this study, the mean age of the patients recorded was 53.72±10.42 years. Frequency of diabetes was 37 (30.8%). Diabetes was significantly associated with hypertension, ischemic heart disease, and chronic kidney disease. Conclusion: The frequency of diabetes in COVID-19 patients in our study was 37 (30.8%). Diabetes was significantly more common in patients with comorbidities such as hypertension, ischemic heart disease, and chronic kidney disease. We recommend proper management of diabetic patients with COVID-19 infection as it can lead to a fatal manifestation of the disease.
Cross-sectional study
Cite
Citations (0)
We previously used isolated adult rat hepatocyte cultures to study the ability of glucose to induce several hepatic mRNAs. However, we found that the optimal insulin concentration required to obtain the glucose effect was greater than 10,000 microU/ml. To test the hypothesis that the requirement for high concentrations of insulin in the culture was due to rapid loss of insulin in hepatocyte cultures, serial measurements of insulin were made at different media insulin concentrations (0-500,000 microU/ml) and glucose concentrations (5.5 and 2.75 mM). In addition, a dose-response relationship was established between media insulin concentrations and the pattern of mRNAs present in the hepatocytes determined by two-dimensional gel electrophoresis of in vitro translation products. We found that at low insulin concentrations (less than 1000 microU/ml), greater than 80% of the insulin was lost to the glassware, whereas at high initial insulin concentrations, approximately 23% of the insulin was lost to the glassware. Placement of media into the hepatocyte culture led to further insulin disappearance with a half-life for insulin of 41.5 h at 10,000 microU/ml and 13.8 h at 100 microU/ml. We found 16 mRNAs were altered by insulin at 5.5 mM glucose and 9 mRNAs were changed by insulin at 27.5 mM glucose. After taking into consideration the distributional and metabolic losses of insulin, all but one mRNA responded to insulin within the physiologic range of portal insulin (less than 1-94 microU/ml). Our data indicate that the hepatocyte culture is an excellent model to study the physiologic effects of insulin on hepatic gene expression.
Cite
Citations (21)
Objective To understand the status of diabetes cognition among COPD patients complicated with diabetes mellitus. Method Totally, 240 COPD patients complicated with diabetes mellitus were investigated by self- designed questionnaire about their knowledge of diabetes mellitus. Results There were significant differences between different gender patients in hypoglycemia symptoms and treatment principles( P 0. 01),among different age patients in diabetes mellitus causes,clinical manifestation and complications,treatment( P 0. 01 or P 0. 05). There were significant differences between among different education background patients in correlation between long- term using glucocorticoid and diabetes and diabetes treatment( P 0. 01 or P 0. 05),among different COPD stages patients in correlation between long- term using glucocorticoid and diabetes,diabetes mellitus causes,hypoglycemia symptoms and treatment principles,diabetes treatment( P 0. 01 or P 0. 05). There were significant differences between different diabetes stages patients in diabetes mellitus causes,clinical manifestation and complications,hypoglycemia symptoms and treatment principles,diabetes treatment( P 0. 01 or P 0. 05). Conclusion The diabetes related health education for COPD patients should be specific according to their situations,in order to control the glucose,promote the prognosis and improve their self- control of glucose.
Cite
Citations (0)
Abstract We estimated effects of diabetes mellitus and metabolic control on long-term change in coronal caries and restorative status using 11-year-follow-up data from the population-based Study of Health in Pomerania. Data of 3731 participants with baseline and 5- and 11-year follow-up information were included. Diabetes was defined via self-reported physician´s diagnosis or intake of glucose-lowering drugs or hemoglobin A1c (HbA1c) ≥6.5% or fasting blood glucose levels ≥11.1 mmol/l. The diabetes status was defined as no diabetes (HbA1c < 6.5% or non-fasting blood glucose <11.1 mmol/l), subjects with known or undetected diabetes mellitus and HbA1c ≤ 7% (well-controlled diabetes), and subjects with known or undetected diabetes mellitus and HbA1c > 7% (poorly-controlled diabetes). The caries status was clinically assessed using the half-mouth method and the Decayed Missing Filled Surfaces (DMFS) index and its component scores were determined. Covariate-adjusted linear mixed models were evaluated. Rates in change in DMFS were significantly higher in subjects with poorly-controlled diabetes compared to subjects without diabetes. Subjects with poorly- and well-controlled diabetes had significantly higher rates in change in Missing Surfaces (MS) compared to subjects without diabetes. For the DFS, rates in change were significantly lower for subjects with well-controlled diabetes and higher for subjects with poorly-controlled diabetes as compared to subjects without diabetes. Concordantly, all rates in change increased proportional to HbA1c levels. Effects were even more pronounced in subjects with diabetes duration of ≥5 years. Subjects with poorly-controlled diabetes are at higher risk for caries progression compared to subjects without diabetes, especially in case of longer disease duration.
Cite
Citations (23)