Influence of novel intravenous complex solution of Ca, Mg and phosphates on blood biochemical parameters of healthy and paretic cows.
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The article describes the dynamics of changes in blood concentrations of the active substances present in the solution after its infusion to healthy cows in comparison to NaCI solution as well as the response of paretic cows to treatment with the new complex solution. Cows received a dose of 400 ml of A1 solution (containing 8.4 g of Ca2+) intravenously. In healthy cows the average calcium concentration in blood serum prior to the test was 2.52 +/- 0.08 mmol/l while 15 min. after the infusion the concentration rose to 3.10 +/- 0.08 mmol/l (p < 0.05) and magnesium concentration rose from 0.61 +/- 0.05 to 1.39 +/- 0.08 mmol/l (p < 0.05). This experiment showed that elevated concentration of non-organic phosphates persisted 1 hour after infusion (p < 0.05). In the second phase of efficacy evaluation of the novel preparation A1 on paretic cows the intravenous injection of 1 ml/kg of body weight of A1 solution increased calcium concentration up to almost normal level (p < 0.05). The level of magnesium in serum 1 h after injection was statistically significantly higher by 63% (p < 0.05) and reached the physiologically normal concentration. 1 h after the infusion of test solution the level of phosphate was higher by 13% (p > 0.05). The rise was statistically not significant. Even though A1 solution undoubtedly produced an increase in glucose concentration in the blood serum, due to wide dispersion of individual measurements and high standard deviation the increase (p > 0.05) in glucose concentration was found insignificant. Most of the treated paretic cows rose within 1-6 h after infusion of 400 ml of solution A1. No relapses were observed. A combination of different salts of calcium and magnesium, non-organic phosphates and glucose with analeptic substance mixed in one solution (A1 solution) administered at a dose of 1 ml/kg of body weight raises concentrations of essential macroelements in blood serum of cattle and promotes improvement of paretic cows condition.Cite
Various nutritious nutritional-supplement gels are being marketed for use in veterinary medicine. This study was designed to determine whether serum calcium, phosphorous, or magnesium concentrations were different between cows given a gel containing calcium chloride as its active ingredient (treated) and cows given inert carrier gel (control). The study revealed a significant (P < 0.01) increase in serum total calcium concentration within 5 minutes of administration of a calcium gel given to cows within 1 hour of parturition. Serum total calcium concentration had returned to baseline value by 24 hours after calcium gel administration. Serum inorganic phosphorus concentration also increased significantly (P < 0.05) after treatment. Significant changes in serum magnesium concentrations were not detected.
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The goal of this study was to determine whether oral administration of sodium phosphate in conjunction with intravenous calcium is more efficaceous than intravenous calcium alone for the treatment of parturient paresis. Thirty cows with parturient paresis were examined and treated by the same veterinarian. The cows were divided randomly into two groups of 15 cows each. Cows in group A received 500 ml of a 40 per cent calcium borogluconate solution containing 15.65 g calcium gluconate and borogluconate, with a supplement of 6 per cent magnesium hypophosphite (9.85 g magnesium hypophosphite) intravenously over a period of approximately 15 min. Cows in group B received the same treatment as well as 350 g of monobasic sodium phosphate (70 g inorganic phosphate, NaH2PO4 2 H2O, Streuli) dissolved in 0.5 litres of distilled water orally via a stomach tube. After treatment, the heart rate, respiratory rate, rectal temperature, superficial body temperature, rumen motility, appetite and defecation of the cows were ...
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Monocalcium phosphate
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Hypochloremia
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Objective To observe the effect of fructose and sodium chloride injection on in vivo environment in treatment of critical illness.Methods One hundred twenty critically sick patients were divided randomly into groups experiment(n=60) and control(n=60).Experimental group first used fructose and sodium chloride injection,250 ml,10ml/min,and control group 0.9% sodium chloride injection,250 ml,10 ml/min.Serum potassium,sodium,chloride,blood glucose were observed before treatment and after.Results The levels of serum potassium,sodium,chloride,blood glucose in absolute value were (0.26±0.25)mmol/L,(1.7±1.7)mmol/L,(1.5±1.3)mmol/L,(0.7±0.5)mmol/L,respectively,in experimental group,and (0.32±0.40)mmol/L,(2.7±3.1)mmol/L,(2.4±2.8)mmol/L and (0.7±0.5)mmol/L,respectively,in control.There was significant difference in levels of serum sodium,chlorine in absolute value between 2 groups before treatment and after(P0.05),but not in serum potassium and blood glucose level (P0.05).Conclusion Fructose and sodium chloride injection can maintain the stability of levels of serum potassium and blood glucose.The changes of serum sodium and chloride were less in using fructose and sodium chloride injection than in using 0.9% sodium chloride.It can provide energy for critically sick patients without causing blood glucose and serum potassium to rise,and is a safe and suitable injection.
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The systemic tolerance of a solution of calcium aspartate and magnesium aspartate was studied in 7 cows. Intravenously administered dosages of 500 ml per cow were well tolerated. A twofold increase of the serum calcium concentration was measured. In 2 cows which were treated with 1000 ml of the solution a threefold increased calcium concentration and heart arrhythmia were found. The clinical efficacy of the solution was demonstrated in a study with 44 hypocalcemic cows. A long lasting increase of the serum calcium as well as an enhanced phosphorus concentration were measurable. In conclusion, the calcium-magnesium-aspartate solution seems to be an efficacious and well tolerated alternative for the treatment of hypocalcemia in cows.
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Objective To compare the effects of volume replacement with sodium potassium magnesium calcium and glucose injection and lactate Ringer's injection on intraoperative blood glucose,electrolytes,and acid-base balence.Methods Thirty patients scheduled for elective gastrointestinal surgery were randomly divided into experimental group(group E,n=16)and control group(group C,n=14).Group E was infused with sodium potassium magnesium calcium and glucose injection while group C was infused with sodium lactate Ringer's injection for volume replacement at the rate of 15 ml·kg-1·h-1.Arterial blood glucose,lactate,electrolytes,and pH were measured before infusion(T0),at the time of the infusion volume reaching 10 ml/kg(T1),20 ml/kg(T2),and 30 ml/kg(T3).Results Compared with T0,blood glucose was increased and pH was decreased(P0.05),while no significant change in lactate w as found in group E after fluid replacement;blood lactate was increased in group C(P0.05);no significant changes in electrolytes were found in both groups.Conclusion Sodium potassium magnesium calcium and glucose injection has the equivalent effects on volume expansion and the maintenance of electrolytes and acid-base balance as sodium lactate Ringer's injection.It can avoid the hyperlactacidemia caused by large volume of lactate Ringer's injection,but large volume infusion of this injection can lead to hyperglycemia.
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Objective
To compare the effects of sodium potassium magnesium calcium and glucose injection and lactate Ringer's injection injected on intraoperative bloodglucose, electrolytes, and acid-base balance in laparoscopic surgery.
Methods
Forty patients scheduled for laparoscopic total hysterectomy were randomly divided into the experiment group(group E, n=25)and the control group(group C, n=25). Group E was infused with sodium potassium magnesium calcium and glucose injection, while group C was infused with sodium lactate Ringer’s injection at the rate of 10 ml/(kg·h). Arteria blood glucose, lactate, electrolytes, and pH were measured before infusion(T0), at the time of the infusion volume reaching 10 ml/kg(T1), 20 ml/kg(T2), and 30 ml/kg(T3).
Results
No significant change in arteria blood glucose, lactate, electrolytes, and pH in group E at T1, T2 and T3 after sodium potassium magnesium calcium and glucose injection injected. In group C, the level of blood lactate was increased, the level of pH was decreased at T2 and T3(P<0.05), and no significant change in arteria blood glucose. No significant changes in electrolytes were found in both groups.
Conclusions
Sodium potassium magnesium calcium and glucose injection has the equivalent effects on maintenance of electrolytes and arteria blood glucose as sodium lactate Ringer’s injection. It can aviod the hyperlactacidemia caused by large volume of lactate Ringer’s injection and maintain the acid-base balance.
Key words:
Sodium potassium magnesium calcium and glucose injection; Laparoscopy; Hysterectomy; Blood glucose; Water-electrolyte balance; Acid-base balance
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DABUINSKAS, S., G. DAUNORAS, A. MATUSEVIEIUS: Dynamics of concentrations of Ca, Mg, P, and glucose after intravenous administration of complex solutions of calcium, magnesium, phosphorus, and glucose to rabbits. Vet. arhiv 74, 115-127, 2004. ABSTRACT Presented in this article are data of pre-clinical rabbit trials using calcium borogluconate and calcium glycerophosphate injection solution of new composition containing phosphorus and magnesium salts, glucose and caffeine. The dynamics of concentrations of Ca, Mg, P, and glucose in the blood serum were studied. This data was then compared with that of the commercial veterinary medicinal product. When rabbits received an intravenous injection of 21 mg/kg of total calcium, a statistically significant increase in calcium concentration in the blood serum was recorded after 15 and 60 min. It was established that when the inorganic phosphorus contained in sodium dihydrophosphate is administered intravenously it has superior bioavailability than inorganic phosphorus contained in calcium glycerophosphate. Pure phosphorus (7.9 mg/kg) contained in the injected sodium dihydrophosphate salt produced a statistically larger increase in inorganic phosphorus concentration after 15 and 60 min. compared to 10 mg/kg of pure phosphorus contained in the calcium glycerophosphate salt injected. Complex injection solution A1 containing calcium borogluconate, sodium dihydrophosphate, and magnesium chloride, were distinguished by the best bioavailability, and compared to the control solution produced the greatest and longest-lasting increase in concentrations of calcium, magnesium, and inorganic phosphorus in blood serum of rabbits. Newly created complex solutions A1 and A2 of different compositions are suitable for parenteral use and are well tolerated by
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