The SDF-1 3'A Genetic Variation Is Correlated with Elevated Intra-tumor Tissue and Circulating Concentration of CXCL12 in Glial Tumors
Seyyed Reza MoosaviHossein KhorramdelazadMasoud AminShirin FatahpoorMozhgan MoogooeiMojgan Noroozi KarimabadMohamadreza Jamali PaghaleAlireza VakilianGholamhossein Hassanshahi
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Pathogenesis
Brain tumor
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The characteristic of the dynamic time is coincidence with its internal pathogenesis.The pathogenesis,however,has different levels.The basic pathogenesis is located at the highest level.The basic pathogenesis guides the specific pathogenesis,and the later is subordinated to the basic one.From the study of the basic pathogenesis we can conclude that therapy in group combinating with individual therapy is the essence of differentiated treatment
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The outcome of any surgical attack on an intracranial tumor depends on the cell type of the lesion and its position within the skull. Tumors composed of glial elements, the true brain tumors, have a much poorer prognosis than lesions with basic cell types that are fibroblastic, glandular, or vascular in origin. Tumors composed of these three types might well be termed intracranial rather than brain tumors, since their cell types are not those of the brain itself. Glial tumors tend to infiltrate the brain to a varying extent, and, for this reason, total extirpation is frequently impossible. Furthermore, since these tumors are invasive, the neurological deficits they produce are due to permanent brain damage and may persist even after the tumor has been extirpated. Nonglial tumors, on the other hand, do not invade the brain but force it to one side. A line of cleavage always exists between such
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Carboplatin
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Many new chemokines have been described in recent years, resulting in a new classification of these chemoattractant proteins. The characterization of the biological functions of most chemokines relates to their ability to induce chemotaxis in circulating inflammatory cells. However, it is now clear that chemokines have a much wider biological role, including angiogenesis, carcinogenesis and involvement in the pathogenesis of HIV infection. Our understanding of the role of chemokines in the pathogenesis of disorders of the lungs and brain outstrips that with regard to disorders of the liver. An increased understanding of the role of chemokines in the pathogenesis of liver disease may lead to the development of novel therapies for hepatic disease.
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Objective:To analyze the pathogenesis and correlative factors of acute upper gastrointestinal hemorrhage.Methods:90 cases with acute upper gastrointestinal hemorrhage from Jan 2010 to Jun 2012 in our hospital were selected as the research objectives.The pathogenesis,predisposition and correlative factors were analyzed using the statistical method.Results:HG,DU,GU were the main pathogenesis of acute upper gastrointestinal hemorrhage.Different pathogeneses had different predispositions(P0.01).Pathogenesis distribution in Youth group,middle-aged group,and older age-group were different(P0.01).Pathogenesis distribute in male and female had no significant difference(P0.05).Conclusions:There are lots of Pathogeneses of acute upper gastrointestinal hemorrhage,and pathogenesis distribution in different age classes is different.
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Brain tumor
Tumor progression
Histopathology
Glial tumor
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We studied the effectiveness of magnetomechanical therapy in the treatment of brain glial tumors using magnetic nanodiscs functionalized with DNA aptamers to human brain tumor glial cells. • Materials and methods. The formation of a model of human glioblastoma was carried out by intracranial injection of tumor cells of glioblastoma obtained from a patient with glioblastoma. Antitumor therapy was carried out using nanodiscs modified with the Gli233 aptamer. The growth of the glial tumor was monitored using NMR tomography. • Results and discussion. Therapy of a glial tumor during 4 sessions of magnetomechanical therapy using a "smart" nanoscalpel in MF (10Hz, 100Oe) led to a significant reduction in its size, while glial tumors in mice that were treated with nanodiscs modified with nonspecific aptamers continued to increase in size. • Conclusion. Microsurgery using three-layer magnetic nanodisks with a quasi-dipole structure (Au/Ni/Au) modified with the specific for glial cells Gli233 aptamer (“smart” nanoscalpel) is effective for the treatment of human glial tumors in the brain.
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U87
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Many new chemokines have been described in recent years, resulting in a new classification of these chemoattractant proteins. The characterization of the biological functions of most chemokines relates to their ability to induce chemotaxis in circulating inflammatory cells. However, it is now clear that chemokines have a much wider biological role, including angiogenesis, carcinogenesis and involvement in the pathogenesis of HIV infection. Our understanding of the role of chemokines in the pathogenesis of disorders of the lungs and brain outstrips that with regard to disorders of the liver. An increased understanding of the role of chemokines in the pathogenesis of liver disease may lead to the development of novel therapies for hepatic disease.
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<i>Objective:</i> To study iron exchange irregularities in experimental animals and patients with glial brain tumors to ascertain the role of the ‘iron component’ in glial brain tumor pathogenesis. <i>Subject and Methods:</i> A suspension of A.101.08 tumor cells was implanted in the cortex of the left-brain hemisphere of rats to model experimentally induced glial brain tumor. At 7 or 14 days after implantation, blood and tissue samples from the tumor, peritumoral tissue, and brain regions were taken for analysis. Blood and plasma samples were obtained from 23 patients as well as biopsy samples taken during tumor removal surgery. Electron resonance spectroscopy was used to determine the concentrations of transferrin iron, transferrin in whole blood and in blood cells, and chelatable and stored iron in the tissues of experimental animals and patients. <i>Results:</i> Hypoferremia was found in rats with both small and large glial brain tumors, whereas hyperferremia was found to be a characteristic of malignant glial brain tumors in humans. We identified statistically significant increases in stored and chelatable iron concentrations in the tumor and peritumoral brain tissue compared to the blood and the adjacent brain tissue (probably normal) in both human malignant glial brain tumors and in rat experimental glial brain tumors. <i>Conclusions:</i> These findings suggest that iron misregulation plays a part in glial brain tumor pathogenesis and this may provide a basis for understanding the association between glial brain tumors and epilepsy.
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Hypertension has complicated pathogenesis.Because of the complexity,in this article the hypertension pathogenesis was divided into several different levels to discuss,which were basic pathogenesis,syndrome pathogenesis,symptom manifestation pathogenesis,disease pathogenesis and micro pathogenesis.The relationship between the above levels and the theoretic and clinical values of each level were analyzed.The significance of syndrome pathogenesis in the study on hypertension pathogenesis was emphasized.
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