Tyrphostins as a promising therapeutic tool in infl ammation-related conditions

Introduction Protein kinases regulate the expression of many genes that are pivotal for inflammation. This review aims to summarise data on a group of small molecules capable to inhibit tyrosine kinases (TYKs), named tyrphostins. They are derivatives of benzylidenemalonitrile that decrease tyrosine phosphorylation, thereby affecting not a single mediator, but cell signalling transduction is affected. No single animal model fully represents the human disease, but these models provide valuable tools to understand particular pathways. In this review, we describe some of the recent investigations on tyrphostins as anti-inflammatory agents in vivo in animal models, and in vitro in cell culture systems. Conclusion It is anticipated that tyrphostins are suitable for the treatment of inflammation-related diseases. Future research is required to understand the mechanisms of their action to pave way for gaining pharmacological