Experimental Study on Autism Caused by Prenatal Exposure to Plasticizer DEHP

Objective: Epidemiological studies have found that exposure to plasticizers in the environment may be associated with autism in preschool children, but laboratory evidence is lacking. To determine whether prenatal exposure to DEHP, a plasticizer, causes autism in offspring mice. Methods: Pregnant mice were randomly divided into four groups: corn oil control group and low, medium and high concentration DEHP exposure group (10 mg/kg, 50 mg/kg, 250 mg/kg). Mice were received continuous intragastric administration of DEHP from the 3rd day to the 17th day of pregnancy. Behavioral characteristics of autism in offspring were assessed after birth. Results: The social ability of offspring was significantly decreased after prenatal exposure to moderate and high concentration DEHP. The female offspring showed repetitive stereotyped behavior and decreased spontaneous activities. Conclusion: Exposure to medium and high concentration of DEHP during embryonic stage can induce autism in offsprings.