Presencia de citosinas en estomatitis aftosa recurrente Recurrent Aphthous Stomatitis and Cytokines Presentation

Summary Recurrent Aphthous Stomatitis (SRA) is an inflammatory chronic disesase, characterized by the presence of recurrent and painful ulcerations in the oral mucous. Objective: To determine the possible role of the TGF- β, IL-1, ICAM-1 and T cells population (CD4, CD8, CD45RO) and histiocitic CD68 in the immunopathogenesis of the SRA. Material and Methods: Twelve patients with the SRA diagnosis and 15 patients without SRA as controls material, were enrolled into the study, all patients were from the Dermatological out patients service at the Hospital Central de Valencia and Facultad de Odontologia from Universidad de Carabobo, Valencia-Venezuela. Age rate was 52.5 years, and the relation gender was 1:1. It was excluded all patients with the diagnosis as Herpes type1 or 2, migratory glossitis, lichen rubber planus and any type of collagen disease. Cytological study from salivary smears, ICAM-1 in saliva (ELISA) and IL-1 by seric levels was showed. Immunohistochemical study was made for TGF- β, CD4, CD3, CD45RO, CD68 expression. Results: ICAM-1 levels were high in SRA patient, TGF- β was more in SRA (++/ +++) patients than no SRA patients (+). T cells CD8 population were more common than T cells CD4 (1568/-190) in SRA patients, histiocitic poblation CD68 was high (++/+++) and IL-1α medium was 149.63 pg/ml. Conclusion: The immunological amplication in the SRA showed as ICAM-1,IL-1, TGF- β and T cells population is the way to get more information about the pathogenesis and systemic implications of SRA, we suggest to all investigators this way in order to understand the pathogenesis of this disease.