A Novel Δ-Thiolactone Scaffold by a Versatile Intramolecular Multicomponent Reaction
2009
The three component reaction of α-aminoacids, mercaptoacetaldehyde and an isocyanide smoothly and stereoselectively yields the novel scaffold 1,2-disubstituted N-alkyl(aryl)-6-oxo thiomorpholine-3-carboxamide. In this communication we present our preliminary results on six compounds derived from this unprecedented reaction.
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