Abstract 17788: Repaired Coarctation is Associated With Central Hypertension, Increased Vessel Stiffness and Abnormal Wave Reflections - A Novel CMR Hemodynamics Study

Introduction: The basis of late cardiovascular mortality following coarctation repair is poorly understood. Although hypertension has been implicated, peripheral systolic pressure (pSBP) has not been shown to be definitively higher in this group. This may be because mortality is more related to central systolic pressure (cSBP) than pSBP. We have developed a novel cardiovascular magnetic resonance (CMR) protocol that allows assessment of cSBP and it components: resistance, compliance and wave reflections. The main aims of this study were i) characterize hemodynamic differences between patients and controls ii) define hemodynamic determinants of cSBP in patients and iii) Identify possible biomarkers amongst covariates associated with LV mass (LVM). Methods: 75 subjects, 50 patients with repaired coarctation, median age 23.5yrs (74% male) and 25 matched controls; 21.0yrs (72% male) were recruited. Ascending aorta area and flow waveforms were obtained using a high temporal resolution (10ms) spiral phase-contr...