Quantifying thermal modifications on laser welded skin tissue
2011
Laser tissue welding is a potential medical treatment method especially on closing cuts implemented during any kind of
surgery. Photothermal effects of laser on tissue should be quantified in order to determine optimal dosimetry parameters.
Polarized light and phase contrast techniques reveal information about extend of thermal change over tissue occurred
during laser welding application. Change in collagen structure in skin tissue stained with hematoxilen and eosin samples
can be detected. In this study, three different near infrared laser wavelengths (809 nm, 980 nm and 1070 nm) were
compared for skin welding efficiency. 1 cm long cuts were treated spot by spot laser application on Wistar rats' dorsal
skin, in vivo. In all laser applications, 0.5 W of optical power was delivered to the tissue, 5 s continuously, resulting in
79.61 J/cm 2 energy density (15.92 W/cm 2 power density) for each spot. The 1st, 4th, 7th, 14th, and 21st days of recovery
period were determined as control days, and skin samples needed for histology were removed on these particular days.
The stained samples were examined under a light microscope. Images were taken with a CCD camera and examined
with imaging software. 809 Nm laser was found to be capable of creating strong full-thickness closure, but thermal
damage was evident. The thermal damage from 980 nm laser welding was found to be more tolerable. The results
showed that 1070 nm laser welding produced noticeably stronger bonds with minimal scar formation.
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