Mapping of the Pulmonary Surfactant SP5 (SFTP2) Locus to 8p21 and Characterization of a Microsatellite Repeat Marker That Shows Frequent Loss of Heterozygosity in Human Carcinomas

Abstract We have identified 4 cosmids at the SFTP2 locus by cDNA hybridization. SFTP2 was mapped using a polymorphic CA repeat and localized to 8p21 by FISH. Allele loss in carcinomas was detected using this PCR marker. Among 11 lung and colon tumors, 6 of 9 informative cases exhibited allelic loss.