Synthesis of 1,4-dipalmitoyl hydroxyproline

1,4-dipalmitoyl hydroxyroline,a skin anti-aging agent used in cosmetics was synthesized from L-hydroxyproline and palmitoyl chloride. The influence factors,such as molar ratio of raw materials,the reaction time,temperature and media of reaction were studied. The appropriate reaction conditions were as follows:volume ratio of acetone 50%,molar ratio of L-hydroxyproline to palmitoyl chloride 1∶2.5,pH 9-10,reaction temperature 15 ℃,reaction time 4 h. After separation,a white solid powder with melting point of 81-85 ℃ was obtained.