Dynamic Eccentric Exercise Improve Glut-1 Expression on Calf Muscle of Diabetic Mice Models

Introduction.Previous study we found that Glut-1 was also expressed on calf muscle of diabetic mice models. Exercise was known as one of diabetic modalities therapy but itwas still unclear whether exercise improved Glut-1 expression on diabetic muscle. Purpose. This study was aimed to investigate the effect of dynamic eccentricexercise on Glut-1 expression. Methode. Multiple low dose of streptozotocin administration was used to induce diabetes at mice.Diabetic mice were run on treadmill with negative inclination (downhill) for 21 minutesas dynamic model of eccentric exercise for calf muscle. Results. A significant improvement ofGlut-1 expression found optimal at -5 degree of declined treadmill. Conclusion. Eccentric exercise improves Glut-1 expression and proposed as an alternative mechanism explained the benefit of exercise on diabetes therapy