Metachronous signet ring cell bladder metastasis as first sing of cancer recurrence

Abstract We describe the case of a 74 year old woman with previous history of gastric signet cell carcinoma who develops bladder metastasis as first sign of recurrence 6 years later. Bladder metastasis due to signet cell carcinoma is extremely rare with only 19 cases reported. Treatment includes radical cystectomy or chemotherapy.