Effect of RANTES on Eosinophil Adhesion to Plates Coated with Recombinant Soluble Intercellular Adhesion Molecule-1 and Expression of β2-lntegrin Adhesion Molecules on Eosinophils

RANTES, a member of the 8-kDa cytokine family, has been shown to possess chemotactic activity for eosinophils. In this study, RANTES augmented isolated human eosinophil adhesion to plates coated with recombinant soluble intercellular adhesion molecule 1. In addition, RANTES did not augment the expression of β2-integrin adhesion molecules (lymphocyte function associated antigen-1α (LFA-1α), LFA-1β, complement receptor type 3 (CR3)) on human eosinophils. These findings suggest that RANTES not only modulates the chemotactic activity of eosinophils but also intensifies the function of eosinophil adhesion without augmenting the expression of β2-integrin adhesion molecules.