Effects of Herba Ephedrae,Honey-fried Herba Ephedrae and Maxingshigan Decoction on Autonomic Activities of Mice

Objective:To discuss the significance of processing and complex prescription with Herba Ephedrae,the effects of Herba Ephedrae,Honey-fried Herba Ephedrae and Maxingshigan decoction on autonomic activities in mice were compared. Methods:110 female Kunming mice were divided into 11 groups,namely normal saline group(NS),ephedrine group(E),high dose Herba Ephedrae group(MH-H),moderate dose Herba Ephedrae group(MH-M),low dose Herba Ephedrae group(MH-L),high dose Honey-fried Herba Ephedrae group(ZMH-H),moderate dose Honey-fried Herba Ephedrae group(ZMH-M),low dose Honey-fried Herba Ephedrae group(ZMH-L),high dose Maxingshigan decoction group (MX-H),moderate dose Maxingshigan decoction group (MX-M) and low dose Maxingshigan decoction group (MX-L). The numbers of autonomic activitiy in 15 minutes before intragastric administration(ig),and after ig 0.5,1,2,3,4 h were determinated. Results:There was interaction between time and groups. There were very sigificant differences between before ig and all time-points after ig(P0.01). 30 minutes after ig,there were significant differences between E and NS,E and ZMH-L,E and MX-L(P0.05). 1 h after ig,there were significant differences between MX-M and NS(P0.05). 3 h after ig,there were significant differences between MX-M and MH-L(P0.05). 30 minutes after ig, both ZMH-L and MX-L could reduce the number of autonomic activity in some extent compare with MH-L. 1 h or 2 h After ig,ZMH-L could reduce the number of autonomic activity in some extent compare with MH-L. 4 h after ig,MX-L could reduce the number of autonomic activity in some extent compare with MH-L. Conclusion:Under the condition of this study,regarding autonomic activity as index, both ZMH-L and MX-L can reduce center stimulation in some extent.