Immunochemical Evidence against the Involvement of Cysteine Conjugate β-lyase in Compound A Nephrotoxicity in Rats

BackgroundCompound A, a degradation product of sevoflurane, causes renal corticomedullary necrosis in rats. Although the toxicity of this compound was originally hypothesized to result from the biotransformation of its cysteine conjugates into toxic thionoacyl halide metabolites by renal cysteine co