Increased mitochondrial substrate sensitivity in skeletal muscle of patients with type 2 diabetes

Steen Larsen,Nis Stride,Martin Hey-Mogensen,Christina Neigaard Hansen,Jesper Løvind Andersen,S. Madsbad,Dorte Worm,Jørn Wulff Helge,Flemming Dela

Increased mitochondrial substrate sensitivity in skeletal muscle of patients with type 2 diabetes

2011

Steen Larsen
Nis Stride
Martin Hey-Mogensen
Christina Neigaard Hansen
Jesper Løvind Andersen
S. Madsbad
Dorte Worm
Jørn Wulff Helge
Flemming Dela

Aims/hypothesis Mitochondrial respiration has been linked to insulin resistance. We studied mitochondrial respiratory capacity and substrate sensitivity in patients with type 2 diabetes (patients), and obese and lean control participants.

Keywords:

Insulin resistance
Respiration
Skeletal muscle
Citrate synthase
Type 2 diabetes
Respiratory system
Internal medicine
Diabetes mellitus
Mitochondrion
Endocrinology
Biology
respiratory capacity
Substrate (chemistry)
in patient

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