Tumor de células de la granulosa juvenil de ovario. Presentación inusual. Reporte de un caso

Los tumores de celulas de la granulosa representan el 2 % de los tumores de ovario. Son clasificados en tipo adulto y juvenil. El juvenil esta asociado a pseudopubertad precoz, menstruacion irregular o sintomas inespecificos como dolor abdominal y masa palpable. Mas del 95 % estan confinados al ovario. Se describe el caso de una paciente de 31 anos de edad, quien consulto por aumento de volumen abdominal y perdida de peso de 6 meses de evolucion. Se diagnostico tumor de ovario derecho. Se practico exeresis del tumor por laparotomia ginecologica con biopsia por corte congelado positiva y cirugia estadificadora. Anatomia patologica reporto tumor del estroma y cordones sexuales sugestivo de tumor de celulas de la granulosa juvenil maligno. La inmunohistoquimica reporto inhibina B positiva. Se concluyo como estadio IIIA2. Esta es una neoplasia rara con un comportamiento variable. El diagnostico preciso esta basado en los estudios histologicos e inmunohistoquimica. Granulose cell tumors represent 2% of ovarian tumors. They are classified as adult type and juvenile type. The juvenile type is associated with precocious pseudopuberty, irregular menstruation or nonspecific symptoms such as abdominal pain and palpable mass. More than 95% are confined to the ovary. A case of a 31-year-old patient is described. The patient consulted for 6-month evolution of increased abdominal volume and weight loss. Right ovary tumor was diagnosed. Tumor excision by gynecological laparotomy with positive frozen cut biopsy and surgical staging were performed. Pathological anatomy reported stromal tumor, and sexual cords suggestive of malignant juvenile granulose cell tumor. Immunohistochemistry reported positive inhibin B. It was concluded as stage IIIA2. This is a rare neoplasm with variable behavior. Accurate diagnosis is based on histological and immunohistochemical studies.