PS3 - 15. Genetic Variation at the SULF2 Locus Affects Hepatic Postprandial Remnant Clearance in Patients with Type 2 Diabetes Mellitus

Type 2 diabetes mellitus (T2DM) is characterized by elevated plasma levels of atherogenic triglyceride-rich lipoproteins (TRL). Recent animal data revealed that heparansulfate proteoglycans (HSPGs) contribute to hepatic clearance of TRL. Hepatic glucosamine-6-O-endosulfatase-2 (SULF2), an enzyme involved in HSPG remodeling, is strongly associated with triglyceride (TG) levels in db/db mice.