Distinct T cell dynamics in lymph nodes during the induction of tolerance and immunity

T cells in lymph nodes during theinduction of antigen-specific immunity or tolerance. At 15–20 h after the induction of immunity, T cells stopped moving andestablished prolonged interactions with DCs. In tolerogenic conditions, despite effective initial T cell activation and proliferation,naive T cells remained motile and established serial brief contacts with multiple DCs. Thus, stable DC–T cell interactions occurduring the induction of priming, whereas brief contacts may contribute to the induction of T cell tolerance.Dendritic cells (DCs) are essential both in the induction of antigen-specific immune responses and in the maintenance of peripheraltolerance