Prelimenary study on pathogenesis of syringoma

Objective To explore the pathogenesis of syringoma in order to cure this disease. Methods The clinical manifestation was observed in 39 cases of syringoma. The serum level of estradiol (E 2), progesterone (Pro), luteinizing hormone(LH) and follicle stimulating hormone (FSH) were detected with radioimmunoassay in all the 30 female cases and 25 normal controls. The expression of estrogen and progesterone receptor (ER and PR) was determined in syringoma tissues using ABC method and anti ER and anti PR monoclonal antibodies. Results Syringoma mainly involved middle aged women. The average level of serum E 2 in female patients was (73±28) ng/ml and its control group, (42±19) ng/ml ( P 0.001). The positive rates of ER and PR in the tissues were 4 % and 20 % respectively. Conclusion The abnormal serum E 2 level may play a role in the pathogenesis of female syringoma.